Monozygotic twins with neuroblastoma MS have a similar molecular profile: a case of twin-to-twin metastasis

British Journal of Cancer, Published online: 11 October 2019; doi:10.1038/s41416-019-0594-3Monozygotic twins with neuroblastoma MS have a similar molecular profile: a case of twin-to-twin metastasis
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research

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The majority of embryonal tumors or childhood blastomas derive from pluripotent progenitors or fetal stem cells that acquire cancer stem cell (CSC) properties: multipotency, self-renewal ability, metastatic potential, chemoresistance, more pronounced levels of drug transporters, enhanced DNA-damage repair mechanisms, and a quiescent state. Neuroblastoma (NB) is considered a neuroendocrine tumor and is the most common extracranial neoplasm in children. NB pathogenesis has frequently been associated with epigenetic dysregulation and a failure to implement a differentiation program. The origin, characteristics, and isolation ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
(Princess Máxima Center for Pediatric Oncology) Both the survival rate and the incidence of neuroblastoma have increased in the last decennia in the Netherlands, as was shown by a study from the Princess M á xima Center. The improved chance of survival and the increase in the number of patients has been greatest in the high risk group; children older than 18 months with a stage 4 neuroblastoma.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Kruyt F, Dolga AM Abstract Brain tumours are among the deadliest tumours being highly resistant to currently available therapies. The proliferative behaviour of gliomas is strongly influenced by ion channel activity. Small-conductance calcium-activated potassium (SK/KCa) channels are a family of ion channels that are associated with cell proliferation and cell survival. A combined treatment of classical anti-cancer agents and pharmacological SK channel modulators has not been addressed yet. We used the gold-derivative auranofin to induce cancer cell death by targeting thioredoxin reductases in combination with CyP...
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research
During cancer progression metabolic reprogramming is observed in parallel to the alternation in transcriptional profiles of malignant cells. Recent studies suggest that metabolic isoenzymes of phosphofructokin...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Hypothesis Source Type: research
(Children's Cancer Institute Australia) An Australian-led international research effort has broken fresh ground in the race to find more effective treatments for the childhood cancer neuroblastoma, by uncovering a new and as-yet unexploited target in cancer cells that therapeutic drugs can be aimed at.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Abstract The in vitro cytotoxic activity on human cancer cell lines of sixteen commercial EOs such as Aloysia triphylla , Boswellia carterii , Boswellia serrata , Cinnamomum zeylanicum , Cistus ladanifer , Citrus × aurantium , Citrus limon , Citrus sinensis , Cymbopogon citratus , Foeniculum vulgare , Illicium verum , Litsea cubeba , Satureja montana , Syzygium aromaticum , Thymus capitatus and Thymus vulgaris was performed using the MTT reduction assay. The screening was carried out on human cancer cells of breast adenocarcinoma (MCF7, T47D and MDA-MDB-231), chronic myelogenous erythroleukaemia (K562) and n...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research
CONCLUSION: Conclusively, the virtual screened drug is better inhibitor than the established drug and can be further subjected for wet lab studies. PMID: 31721713 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
CONCLUSIONS: Therefore, given the fact that miR-223-3p suppressed FOXO1 expression to promote NB progression, targeting miR-223-3p may be an effective method for NB treatment. PMID: 31696486 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: SNHG1 conduced to tumorigenesis and mechanism by upregulating PLK4 and by acting as miR-338-3p sponge in neuroblastoma. PMID: 31696485 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
(Texas Tech University Health Sciences Center) Neuroblastoma, the most common cancer outside of the brain in infants and young children, often fails to respond to therapy. To improve treatment outcomes for these patients, C. Patrick Reynolds, M.D., Ph.D., director of the Texas Tech University Health Sciences Center School of Medicine's Cancer Center, and a team of colleagues completed a study using fenretinide to boost the effects of venetoclax, an inhibitor of a protein (BCL-2) that helps neuroblastoma cells survive and grow.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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