Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration

Publication date: Available online 9 October 2019Source: Seminars in Cell &Developmental BiologyAuthor(s): Michael A. Flinn, Brian A. Link, Caitlin C. O’MearaAbstractThe response of the adult mammalian heart to injury such as myocardial infarction has long been described as primarily fibrotic scarring and adverse remodeling with little to no regeneration of cardiomyocytes. Emerging studies have challenged this paradigm by demonstrating that, indeed, adult mammalian cardiomyocytes are capable of completing cytokinesis albeit at levels vastly insufficient to compensate for the loss of functional cardiomyocytes following ischemic injury. Thus, there is great interest in identifying mechanisms to guide adult cardiomyocyte cell cycle re-entry and facilitate endogenous heart regeneration. The Hippo signaling pathway is a core kinase cascade that functions to suppress the transcriptional co-activators Yap and Taz by phosphorylation and therefore cytoplasmic retention or phospho-degradation. This pathway has recently sparked interest in the field of cardiac regeneration as inhibition of Hippo kinase signaling or overdriving the transcriptional co-activator, Yap, significantly promotes proliferation of terminally differentiated adult mammalian cardiomyocytes and can restore function in failing mouse hearts. Thus, the Hippo pathway is an attractive therapeutic target for promoting cardiomyocyte renewal and cardiac regeneration. Although the core kinases and transcriptional ac...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research

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Source: Medscape Today Headlines - Category: Consumer Health News Tags: Resource Center Source Type: news
HEART attack is a medical emergency and is the result of unhealthy lifestyle decisions such as eating an unhealthy diet. Fortunately, eating certain foods can lower a person ’s risk of developing the deadly condition, including a popular snack.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionsIn this observational analysis of T2D and ASCVD, baseline β-blocker use was not associated with risks for severe hypoglycemia yet also was not associated with CV risk reduction over 3 years of follow-up, supporting a randomized examination of chronic β-blocker therapy in this patient population. (TECOS number, NCT00790205).
Source: American Heart Journal - Category: Cardiology Source Type: research
ute;nez-Sánchez C, Arias-Mendoza A PMID: 31702743 [PubMed - in process]
Source: Archivos de Cardiologia de Mexico - Category: Cardiology Authors: Tags: Arch Cardiol Mex Source Type: research
Authors: Burda R, Morochovič R, Némethová M, Burda J Abstract The aim of this study was to verify the possibility of preparation and effectiveness of the use of blood plasma containing an effector of ischemic tolerance activated by applying two sublethal stresses to a donor. As sublethal stresses, two periods of 20-minute hindlimb ischemia were used with a two-day interval between them. Active plasma was isolated six hours after the second hindlimb ischemia. The effectiveness of active plasma as well as remote postconditioning was tested after three hours of tourniquet-induced ischemia on the gastroc...
Source: Journal of Plastic Surgery and Hand Surgery - Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research
ConclusionDiabetes-induced significant decline in orexin B levels in the plasma along with a decrease in the expression of sirtuin 1 and HIF-1α in the heart following ischemia-reperfusion injury may possibly contribute in exacerbating the myocardial injury and vascular dysfunction.
Source: Life Sciences - Category: Biology Source Type: research
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: VEGFR-TKIs are associated with a small increase in risk of patients developing hypertension, arterial thrombotic events, thrombocytopenia, and bleeding. Previous studies overestimated the actual risk associated with VEGFR-TKIs by analyzing the outcome with the lower baseline risk. PMID: 31698959 [PubMed - as supplied by publisher]
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Conclusions. Our results show that the division of MI diagnoses to STEMI and NSTEMI is not reliable in the Finnish HDR. These diagnoses should not be used as outcomes in scientific research without additional verification from the original ECGs. PMID: 31701776 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Publication date: Available online 9 November 2019Source: Canadian Journal of CardiologyAuthor(s): Daniel H. KimAbstractCardiogenic Shock (CS) accounts for 15% of all Cardiac Intensive Care Unit admissions, with Acute Myocardial Infarction Cardiogenic Shock (AMICS) accounting for 30% of these. In contrast to other areas in cardiac care where survival has continued to improve over the last two decades, CS still carries a mortality of around 40%. Temporary Mechanical Circulatory Support (tMCS) therapies have shown inconsistent results in improving outcomes in CS, with the overall evidence not supporting its use, at least not...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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