University of Edinburgh Study Finds Antimicrobial Bacteria in Hospital Wastewater in Research That Has Implications for Microbiologists
The highly infectious bacteria can survive treatment at local sewage plants and enter the food chain of surrounding populations, the study revealed Researchers at the University of Edinburgh (UE) in Scotland found large amounts of antimicrobial-resistance (AMR) genes in hospital wastewater. These findings will be of interest to microbiologists and clinical laboratory managers, as the […]
ConclusionsMany drugs that were previously effective against MDRAB, have lost their effectiveness. Currently, there is no effective drug to fight MDRAB, apart from colistin. Thus, it is clear that new drugs and treatment protocols should be developed urgently.
Publication date: Available online 1 June 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Vasiliki Galani, Costas C. Papagiannitsis, Efi Petinaki
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Fereshteh Ezadi, Ailar Jamali, Ahmad Heidari, Naemeh Javid, Abdollah Ardebili
Microbial Drug Resistance, Ahead of Print.
ConclusionWhole genome sequencing enables the prediction of antimicrobial resistance in Gram-negative bacteria. We present a tool that provides an in silico antibiogram for eight drugs. Predictions are accompanied with a reliability index that may further facilitate the decision making process. The demo version of the tool with pre-processed samples is available at https://vancampn.shinyapps.io/wgs2amr/. The stand-alone version of the predictor is available at https://github.com/pieterjanvc/wgs2amr/.
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Mohsin Khurshid, Muhammad Hidayat Rasool, Usman Ali Ashfaq, Bilal Aslam, Muhammad Waseem, Qingqing Xu, Xuefei Zhang, Qinglan Guo, Minggui Wang
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Jason Farlow, Maia Nozadze, Nino Mitaishvili, Adam Kotorashvili, Nato Kotoria, Keto Arobelidze, Viktoria Tavadze, Tsiuri Simsive, Paata Imnadze, Nabil Latif, Mikeljon P. Nikolich, Michael Washington, Mary K. Hinkle, Paul Kwon, Nino Trapaidze
Abstract SUMMARYAntimicrobial-resistant ESKAPE ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens represent a global threat to human health. The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antimicrobial resistance surveillance. This looming health threat has restimulated interest in the development of new...
Using a combination of short- and long-read DNA sequencing, we have investigated the location of antibiotic resistance genes and characterized mobile genetic elements (MGEs) in three clinical multi-drug resistant Acinetobacter baumannii. The isolates, collected in Bolivia, clustered separately with three different international clonal lineages. We found a diverse array of transposons, plasmids and resistance islands related to different insertion sequence (IS) elements, which were located in both the chromosome and in plasmids, which conferred resistance to multiple antimicrobials, including carbapenems. Carbapenem resista...
Publication date: Available online 1 May 2020Source: Veterinary MicrobiologyAuthor(s): Grazieli Maboni, Mauricio Seguel, Ana Lorton, Susan Sanchez