ChAdOx1 85A Aerosol Versus Intramuscular Vaccination in Healthy Adults (TB039)
Conditions: Mycobacterium Tuberculosis, Protection Against; Tuberculosis Interventions: Biological: ChadOx1 85A - aerosol; Biological: ChadOx1 85A - IM Sponsors: François Spertini; University of Oxford Recruiting
Measles, mumps, and tuberculosisâthese are all diseases the general public has long disregarded as active threats. Yet, these highly infectious and potentially life-threatening diseases once considered eradicated have been resurfacing across the United States. Measles, for example, was declared eliminated in 2000 by the CDC, yet this year alone more than 1,200 individual cases have been confirmed in 30 states. This outbreak represents the greatest number of reported cases for the disease in the United States since 1992.1 While the ongoing anti-vaccination movement may not be the cause of these reappearanc...
(Trinity College Dublin) By understanding how, when, and why badgers move from one social group to another, researchers hope information gleaned from GPS devices will help them tailor vaccination programs to reduce the spread of bovine tuberculosis.
AbstractThe interleukin (IL)-12/interferon(IFN) γ axis plays an important role in the control of mycobacterial diseases as demonstrated by the increased susceptibility to mycobacterial species in patients with an inborn error of the IL-12-dependent IFNγ immunity. Here, we report a novel mutation in theIL-12R β1 gene in a female Pakistani patient who was born in a consanguineous marriage and developed severe bacille Calmette –Guérin (BCG) infection and recurrent tuberculosis. After reviewing the patient’s clinical records, she was investigated for IL-12/IFNγ defects using enzyme-lin...
ConclusionThe study signifies the development of a potent therapeutic agent comprising of a complex of anti-TB agent (fatty acids) and antioxidants (carotenoids) from the CGF-extracted spent biomass of C. vulgaris.Graphical abstract
Bill Gates, who is currently on a three-day visit to India, said: "Our biggest work has been broadly in the health area helping to get new vaccines introduced, helping to look at innovations in some of the disease-specific areas, like tuberculosis or visceral leishmaniasis (VL) or lymphatic filariasis (LF)."
In conclusion, CASAC adjuvant has great potential to enhance immunogenicity elicited against HspX antigen, which could be an alternative regimen to improve the efficacy of future therapeutic vaccine against Mycobacterium tuberculosis.
(Colorado State University) The research led by assistant professors Marcela Henao-Tamayo and Brendan Podell is part of a $44.8 million, seven-year award to the Infectious Disease Research Institute, based in Seattle.
This article updates our laboratory's systematic search for antigens using bioinformatics tools to clarify the Mtb H37Rv Rv3632 protein's topology and location. This article reports a C-terminal region consisting of peptides 39255 and 39256 (81Thr-Arg114) having high specific binding regarding two infection-related cell lines (A549 and U937); they inhibited mycobacterial entry to U937 cells in a concentration-dependent manner. Rv3632 forms part of the mycobacterial cell envelope, formed by six linear synthetic peptides. Circular dichroism enabled determining the protein's secondary structure. It was also found that peptide...
CONCLUSION: A ChAdOx1 85A prime - MVA85A boost is well tolerated and immunogenic in healthy UK adults. PMID: 31735500 [PubMed - as supplied by publisher]
This study provided clues for developing therapies against tuberculosis by targeting ESAT6. PMID: 31735338 [PubMed - as supplied by publisher]