Viagra May Enhance Stem Cell Treatments For Leukemia

Viagra when combined with another FDA-approved drug may enhance the collection of blood stem cells, used in the treatment of leukemia and several other diseases.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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This article reviews the efficacy data from completed and ongoing early phase clinical trials of non-JAKi agents for chronic phase MF. The article also illuminates some of the challenges of myelofibrosis drug development.Expert opinion: Most non-JAKi agents tested so far have shown modest benefit in improving the efficacy of ruxolitinib. Several novel agents such as BET inhibitor- CPI-0610, activin receptor ligand trap- luspatercept, recombinant pentraxin-PRM-151, telomerase inhibitor- imetelstat and navitoclax, have shown promising activity; however, they require vigorous evaluation in randomized controlled trials to unde...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Contributors : Huacheng Luo ; Suming HuangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAberrant activation of the TAL1 oncogene is associated with up to 60% of T-ALL patients and is involved in CTCF mediated genome organization within the TAL1 locus, suggesting the importance of the CTCF boundary in the molecular pathogenesis of T-ALL. Here, we show that deletion of CTCF binding site (CBS) or alternation of CTCF boundary orientation alters expression of the TAL1 oncogene in a cell context dependent manner. D...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
Leukemia stem cells (LSCs) in play an important role in the initiation, relapse, and progression of acute myeloid leukemia (AML), and in the development of chemotherapeutic drug resistance in AML. Studies rega...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
AbstractBackgroundThe high-risk refractory and/or relapsed (R/R) childhood acute leukemia prognosis is poor, and allogeneic stem cell transplantation (allo-HSCT) is the most prudent treatment modality. However, there are limited matched sibling donors (MSDs), and alternative donors (ADs) are the main source for allo-HSCT. Thus, we evaluated the clinical efficacy of AD peripheral allo-HSCT for treating high-risk R/R childhood acute leukemia.MethodsWe assessed 111 children who underwent allo-HSCT at the Affiliated Cancer Hospital of Zhengzhou University between October 2006 and July 2019. The patients were divided in the MSD...
Source: Experimental Hematology and Oncology - Category: Cancer & Oncology Source Type: research
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell proliferation caused by a constitutively active tyrosine kinase called BCR-ABL. The BCR-ABL fusion gene results from a translocation between chromosomes 9 and 22. The development of targeted tyrosine kinase inhibitors (TKIs) has transformed this previously fatal illness into a chronic disease.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research
Conditions:   Haematological Malignancy;   Acute Leukemia;   Myelodysplastic Syndromes;   Hemoglobinopathy in Children;   Bone Marrow Aplasia;   Severe Combined Immunodeficiency Intervention:   Other: Physical activity program Sponsor:   Centre Leon Berard Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Contributor : Ryan N DelgadoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusNeural stem cells (NSCs) in the developing and postnatal brain have distinct positional identities that dictate the types of neurons they generate. While morphogens initially establish NSC positional identity in the neural tube, it is unclear how such regional differences are maintained as the forebrain grows much larger and anatomically more complex. We found that the maintenance of NSC positional identity requires a Mixed-lineage leukemia 1 (Mll1)-dependent epigenetic memory system. After establishme...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research
Genome editing of donor-derived T-cells to generate allogenic chimeric antigen receptor-modified T cells: Optimizing αβ T cell-depleted haploidentical hematopoietic stem cell transplantation. Haematologica. 2020 Apr 02;: Authors: Wiebking V, Lee CM, Mostrel N, Lahiri P, Bak R, Bao G, Roncarolo MG, Bertaina A, Porteus MH Abstract Allogeneic hematopoietic stem cell transplantation is an effective therapy for high-risk leukemias. In children, graft manipulation based on the selective removal of αβ T cells and B cells has been shown to reduce the risk of acute and chronic graft-versu...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
, Sanz J, Schmid C, Shouval R, Spyridonidis A, Versluis J, Vey N, Savani BN, Nagler A, Mohty M Abstract The FMS-like tyrosine kinase 3 (FLT3) gene is mutated in 25-30% of patients with acute myeloid leukemia . Because of the poor prognosis associated with FMS-like tyrosine kinase 3 internal tandem duplication mutated Acute myeloid leukemia, allogeneic-hematopoietic stem-cell transplantation was commonly performed in first complete remission. Remarkable progress has been made in frontline treatments with the incorporation of FLT3 inhibitors and the development of highly sensitive minimal/measurable residual disease...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
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