A Virus in Koala DNA Shows Evolution in Action

Many animals, including humans, have DNA left over from ancient viral infections. In koalas, researchers are studying the process in real time.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Genetics and Heredity Koalas DNA (Deoxyribonucleic Acid) Viruses Evolution (Biology) Chlamydia RNA (Ribonucleic Acid) your-feed-science William Theurkauf University of Massachusetts Cell (Journal) Source Type: news

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Publication date: Available online 15 October 2019Source: Brain, Behavior, and ImmunityAuthor(s): Jason J. Woods, Kathryn A. Skelding, Kristy L. Martin, Ritambhara Aryal, Estelle Sontag, Daniel M. Johnstone, Jay C. Horvat, Philip M. Hansbro, Elizabeth A. MilwardAbstractAlzheimer’s disease, the most common form of dementia, was first formally described in 1907 yet its etiology has remained elusive. Recent proposals that Aβ peptide may be part of the brain immune response have revived longstanding contention about the possibility of causal relationships between brain pathogens and Alzheimer's disease. Research has...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Many intracellular bacteria, including the obligate intracellular pathogen Chlamydia trachomatis, grow within a membrane-bound bacterium-containing vacuole (BCV). Secreted cytosolic effectors modulate host activity, but an understanding of the host-pathogen interactions that occur at the BCV membrane is limited by the difficulty in purifying membrane fractions from infected host cells. We used the ascorbate peroxidase (APEX2) proximity labeling system, which labels proximal proteins with biotin in vivo, to study the protein-protein interactions that occur at the chlamydial vacuolar, or inclusion, membrane. An in vivo under...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research
In this study, we assessed the bacterial composition of the rectal microbiota associated with CT and/or NG infections in a cohort of men reporting unsafe rectal intercourse. A total of 125 rectal swabs were collected and four groups were compared: non-infected subjects (n = 53), patients with CT (n = 37), or NG rectal infection (n = 17) and patients with contemporary positivity for CT/NG (n = 18). CT and NG infections were detected by a real-time commercial test and the rectal microbiota composition was analyzed from rectal swabs through sequencing of the hypervariable V3-V4 regions of the 16S rRNA gene. The rectal microbi...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Review (26 studies, n=4,791) found antibiotic treatment may reduce risk of active trachoma and ocular infection in people infected with C trachomatis, compared to no treatment/placebo, but treatment effect size in individuals is uncertain.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
The Australian research is the first to find the sexually transmitted disease in testicular tissue biopsies of infertile men with no identified cause for their infertility.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Conclusion. In this study, a multiplex qPCR assay with high sensitivity and specificity for rapid (≤2.0 h) and accurate diagnosis of C. trachomatis was developed. The qPCR assay has the potential to be used as a routine diagnostic method in clinical microbiology laboratories. PMID: 31613208 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
Abstract Alzheimer's disease, the most common form of dementia, was first formally described in 1907 yet its etiology has remained elusive. Recent proposals that Aβ peptide may be part of the brain immune response have revived longstanding contention about the possibility of causal relationships between brain pathogens and Alzheimer's disease. Research has focused on infectious pathogens that may colonize the brain such as herpes simplex type I. Some researchers have proposed the respiratory bacteria Chlamydia pneumoniae may also be implicated in Alzheimer's disease, however this remains controversial. This r...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
Chlamydia is the most common sexually transmitted infection in the United States. Expedited partner therapy is the practice of prescribing antibiotic therapy to the sexual partner(s) of a patient infected with a sexually transmitted infection, without an evaluation by a provider. Primary care providers often encourage partner notification, but research suggests that is not sufficient in ensuring successful partner treatment or reducing patient reinfection. All primary care providers must be comfortable prescribing expedited partner therapy to at-risk populations.
Source: The Journal for Nurse Practitioners - Category: Nursing Authors: Tags: Case Challenge Source Type: research
Metabolic adaptation to the host cell is important for obligate intracellular pathogens such as Chlamydia trachomatis (Ct). Here we infer the flux differences for Ct from proteome and qRT-PCR data by comprehensive pathway modeling. We compare the comparatively inert infectious elementary body (EB) and the active replicative reticulate body (RB) systematically using a genome-scale metabolic model with 321 metabolites and 277 reactions. This did yield 84 extreme pathways based on a published proteomics dataset at three different time points of infection. Validation of predictions was done by quantitative RT-PCR of enzyme mRN...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Sexually transmitted infections (STIs), also referred to as sexually transmitted diseases, are at a record high in the U.S. Sexually transmitted infections increased for the fifth consecutive year, with nearly 2.5 million combined cases of chlamydia, gonorrhea and syphilis, according to the annual Sexually Transmitted Disease Surveillance Report released by the Centers for Disease Control [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
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