Pneumococcal serotype trends, surveillance and risk factors in UK adult pneumonia, 201318

Prospective cohort study (n=2,934) found that the incidence of pneumococcal community acquired pneumonia increased from 32.2 to 48.2 per 100 000 population, predominantly due to non-vaccine type serotype and serotype 3.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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ConclusionAdults who received pneumococcal vaccines experienced reduced rates of hospital versus ICU admissions due to pneumonia infection.
Source: Journal of Pharmaceutical Health Services Research - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research
This study was performed to investigate the serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae in Asian countries. A prospective surveillance study on S. pneumoniae collected from adult patients (≥50 years old) with invasive pneumococcal disease or community-acquired pneumonia was performed at 66 hospitals in Asian countries (Korea, China, Malaysia, Singapore, the Philippines, and Thailand) in 2012-2017. Serotyping and antimicrobial susceptibility tests of 850 pneumococcal isolates were performed. The proportions of isolates with serotypes covered by 13-valent pneumococcal conjugate vac...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Condition:   Pneumonia, Pneumococcal Intervention:   Biological: 15-Valent Pneumococcal Conjugate Vaccine Sponsors:   Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd;   Hebei Center for Disease Control and Prevention;   Laishui Center for Disease Control and Prevention;   National Institutes for Food and Drug Control, China;   Simoon Record Pharma Information Consulting Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Different abnormalities account for the increased risk of viral and bacterial infection in patients with diabetes mellitus (DM). Main irregularities include: decreased CD4/CD8 lymphocyte ratios, reduced monocyte phagocytic function and defects in interleukin-2 production [1 –6]. Individuals with DM are 6 time more likely to be hospitalized and 3 times more likely to die from complications of influenza or pneumonia when compared to those in general population [7]. People with DM have higher rates of hepatitis B due to contact with infected blood or through improper eq uipment use (glucose monitoring devices or infected needles) [8].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Immaturity of the immune system contributes to poor vaccine responses in early life. Germinal center (GC) activation is limited due to poorly developed follicular dendritic cells (FDC), causing generation of few antibody-secreting cells (ASCs) with limited survival and transient antibody responses. Herein, we compared the potential of five adjuvants, namely LT-K63, mmCT, MF59, IC31, and alum to overcome limitations of the neonatal immune system and to enhance and prolong responses of neonatal mice to a pneumococcal conjugate vaccine Pnc1-TT. The adjuvants LT-K63, mmCT, MF59, and IC31 significantly enhanced GC formation and...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Streptococcus pneumoniae is the leading cause of bacterial infections in children, including meningitis, bacteremia, bacteremic pneumonia, empyema, and mucosal infections such as otitis media and non-bacteremic pneumonia. After the implementation of pneumococcal conjugate vaccines (PCVs), worldwide, the burden of invasive pneumococcal diseases (IPDs) and non-invasive pneumococcal diseases due to vaccine serotypes (VTs) greatly decreased in children.1 However, since 2015, several European countries have reported an increased incidence of IPDs due to non-vaccine serotypes (NVTs), which seemed variable across countries in ter...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: European Paediatric Association Source Type: research
Conclusions: The PHiD-CV vaccination program in Brazil has resulted in important reductions of pneumococcal disease and substantial cost savings. Instead of switching PCVs, expanding vaccine coverage or investing in other health care interventions would be a more efficient use of resources to improve the health of the population in Brazil.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
Conditions:   Pneumonia;   Respiratory Tract Diseases;   Respiratory Tract Infections Interventions:   Biological: Protein based pneumococcal vaccine(Low dose);   Biological: Protein based pneumococcal vaccine placebo(Low dose);   Biological: Protein based pneumococcal vaccine(Middle dose);   Biological: Protein based pneumococcal vaccine placebo(Middle dose);   Biological: Protein based pneu mococcal vaccine(High dose);   Biological: Protein based pneumococcal vaccine placebo(High dose) Sponsors:   CanSino Biologics Inc.;   Henan Cen...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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