Men who conceive with assisted reproduction at increased prostate cancer risk

(Reuters Health) - Men who conceive children using assisted reproduction techniques (ART) like in vitro fertilization (IVF) are more likely to develop prostate cancer and may benefit from screening, a recent study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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CONCLUSIONS: The rate of overall complications after TRUS was low. The most common complications requiring emergency attendances and hospitalisations were gross haematuria and acute urinary retention, respectively. Prostate volume>48 cc increased the risk of post-biopsy urinary retention. PMID: 31601774 [PubMed - as supplied by publisher]
Source: Hong Kong Medical Journal - Category: General Medicine Tags: Hong Kong Med J Source Type: research
CONCLUSIONS: EHMT2 was highly expressed in PCa, and its expression is closely correlated with tumor stage and poor prognosis of PCa patients. EHMT2 promoted the malignant progression of PCa by inhibiting PI3K/AKT/mTOR pathway. PMID: 31599405 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
In this study, we examined this proposed use of a limited percent Gleason pattern 4 (%GP4) to identify candidates of active surveillance among 315 patients who underwent radical prostatectomy for prostate cancer with a GS of 6 or 3+4=7 via needle biopsy. The latter cases were divided into 4 groups using highest or overall %GP4 cut-off values of 5% and 10% as determined from prostate needle biopsies. The frequency of adverse pathology and risk of biochemical recurrence were compared between the GS 6 and both GS 3+4=7 groups. Adverse pathology was defined as a GS 4+3=7 or higher, pT3b staging or positive lymph node metastasi...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
ROBERT DE NIRO has enjoyed enduring success an actor, with a career spanning decades. In 2003, the actor was diagnosed with prostate cancer. What are the key warning signs and how can the cancer be treated?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractPurposeTo provide a snapshot of toxicities and oncologic outcomes of Abiraterone (AA) and Enzalutamide (EZ) in a chemo-na ïve metastatic castration-resistant prostate cancer (mCPRC) population from a longitudinal real-life multicenter cohort.MethodsWe prospectively collected data on chemo-na ïve mCRPC patients treated with AA or EZ. Primary outcomes were PSA response, oncologic outcomes and toxicity profile. The Kaplan–Meier method was used to compare differences in terms of progression-free survival (PFS) between AA vs EZ and high- vs low-volume disease cohorts. Univariable and mult ivariable Cox r...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionsThese findings suggest that IDO expression is a mechanism of immune evasion used by prostate cancer and that future clinical trials using T-cell-based immune strategies might best include IDO inhibition.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
Publication date: Available online 10 October 2019Source: Biosensors and BioelectronicsAuthor(s): Sungwook Park, Minsoo Kim, Dongkap Kim, Seok Ho Kang, Kwan Hyi Lee, Youngdo JeongAbstractIon-sensitive field-effect transistor (ISFET) as a biosensor facilitates a process of data-acquisition through label-free and real-time monitoring. Direct quantification of a biomarker in serum is challenging in ISFET biosensor since charged proteins in serum interfere transduction to electrical signals. Here, we report the fabrication of protein blocking layers (PBLs) with intended interfacial charges to minimize non-specific protein bind...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 11 October 2019Source: European UrologyAuthor(s): Giancarlo Marra, Roland Van Velthoven, Massimo Valerio
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 10 October 2019Source: European UrologyAuthor(s): Michael Froehner, Rainer Koch, Christian Thomas
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionsThe MSKCC nomogram, CAPRA score, and CPG risk grouping system performed better in discriminating prostate cancer death than the D’Amico and D’Amico-derived systems (NICE, GUROC, EAU, AUA, and NCCN). Use of these tools may improve clinical decision making.Patient summaryThere are numerous pretreatment risk classification tools that can aid treatment decision for prostate cancer. We systematically compared the prognostic performance of the most commonly used tools in a large cohort of Swedish men with prostate cancer. The Memorial Sloan Kettering Cancer Center nomogram, Cancer of the Prostate Risk Asse...
Source: European Urology - Category: Urology & Nephrology Source Type: research
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