The Candida albicans exotoxin Candidalysin promotes alcohol-associated liver disease

Alcohol-associated liver disease is one of the most prevalent liver diseases worldwide[1], and the leading cause of liver transplantation in the U.S.[2]. Alcohol-related liver disease is associated with changes in the intestinal microbiota. Gut dysbiosis induces intestinal inflammation and gut barrier dysfunction, which allows viable bacteria, bacterial (such as lipopolysaccharides (LPS)) and fungal products (such as β-glucan) to translocate to the liver. Bacteria and microbial products bind to pathogen recognition receptors causing an inflammatory response of resident Kupffer cells and an infiltration of macrophages.

Source: Journal of Hepatology - October 9, 2019 Category: Gastroenterology Authors: Huikuan Chu, Yi Duan, Sonja Lang, Lu Jiang, Yanhan Wang, Cristina Llorente, Jinyuan Liu, Selene Mogavero, Francisco Bosques-Padilla, Juan G. Abraldes, Victor Vargas, Xin M. Tu, Ling Yang, Xiaohua Hou, Bernhard Hube, Peter St ärkel, Bernd Schnabl Source Type: research