L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet

Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disorder. NAFLD, associated lipotoxicity, fibrosis, oxidative stress, and altered mitochondrial metabolism, is responsible for systemic inflammation, which contributes to organ dysfunction in extrahepatic tissues, including the heart.We investigated the ability of L-carnitine (LC) to oppose the pathogenic mechanisms underlying NAFLD progression and associated heart dysfunction, in a mouse model of methionine-choline-deficient diet (MCDD).

Source: Digestive and Liver Disease - October 9, 2019 Category: Gastroenterology Authors: Giulia Mollica, Pamela Senesi, Roberto Codella, Fernanda Vacante, Anna Montesano, Livio Luzi, Ileana Terruzzi Tags: Liver, Pancreas and Biliary Tract Source Type: research