Recognising and understanding cryopyrin-associated periodic syndrome in adults.

Recognising and understanding cryopyrin-associated periodic syndrome in adults. Br J Nurs. 2019 Oct 10;28(18):1180-1186 Authors: Williams R, Hawkins P, Lane T Abstract Cryopyrin-associated periodic syndrome (CAPS) is a group of rare hereditary autoinflammatory diseases characterised by recurrent flares of mild to severe systemic inflammation and fever. CAPS is the umbrella term for a spectrum of individual conditions, namely familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and neonatal-onset multisystem inflammatory disease (NOMID), also known as chronic infantile neurologic, cutaneous and articular (CINCA) syndrome. The flare symptoms include fever, fatigue, rashes, headaches, arthralgia and myalgia that can last for a few hours or for several days. These symptoms are debilitating, contributing to poor quality of life for patients if left untreated. Serious life-changing complications such as hearing loss, blindness and AA amyloidosis resulting in kidney failure can occur. Until recently, treatment of the disease was symptomatic using non-steroidal anti-inflammatory and immunosuppressant drugs with limited success. In contrast, biological treatments targeting interleukin 1 (IL-1) have proved remarkably effective, often associated with complete and sustained disease remission, vastly improved quality of life and avoidance of serious long-term complications. PMID: 31597069 [PubMed - in process]
Source: British Journal of Nursing - Category: Nursing Authors: Tags: Br J Nurs Source Type: research

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Publication date: November 2019Source: International Journal of Industrial Ergonomics, Volume 74Author(s): Trond Kongsvik, Øyvind Dahl, Ingunn Marie Holmen, Trine ThorvaldsenAbstractFew studies have explored the potential connection between safety climate and health issues. However, some recent research findings indicate that a poor safety climate can be considered a stressor that may be associated with physical symptoms and musculoskeletal complaints. This link is further explored in the present study on the basis of a questionnaire study of 446 sharp-end workers in the Norwegian aquaculture industry. The analysis ...
Source: International Journal of Industrial Ergonomics - Category: Occupational Health Source Type: research
ConclusionCurrent UK practice does not reflect recommendations from the AAGL or BSGE. Deficiencies were identified in pre-operative evaluation, local governance procedures, and consenting practices regarding use of a power morcellator and risk of occult leiomyosarcoma.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
This study aimed to provide information on the burden of illness and health-related quality of life (HRQoL) in children with epilepsy who experience prolonged acute convulsive seizures (PACS) in the community setting, and to investigate factors that may predict poor HRQoL in this population.MethodsNoninstitutionalized children (aged 3–16 years) who had experienced at least one PACS within the past year and had currently prescribed PACS rescue medication were enrolled in a cross-sectional study in Germany, Italy, Spain, and the United Kingdom (Practices in Emergency and Rescue medication For Epilepsy managed with Co...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Butterfly Network, the digital health unicorn democratizing medical imaging, is continuing to add new applications for its handheld, single probe, smartphone-connected ultrasound technology. The Butterfly iQ, the multi-purpose pocket-sized ultrasound...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Cardiology Critical Care Emergency Medicine Exclusive News Ob/Gyn Pediatrics Radiology Surgery Urology Vascular Surgery Source Type: blogs
We report eight cases of intraosseous venous malformation that were inappropriately labelled as haemangioma by clinicians, pathologists, and radiologists. We highlight tailored management, and describe the clinical features, results of investigations to aid accurate designation (histological and immunohistochemical, including GLUT1 staining and cross-sectional imaging), and outcomes.
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Condition:   Migraine Interventions:   Drug: AXS-07 (MoSEIC meloxicam and rizatriptan);   Drug: Placebo Sponsor:   Axsome Therapeutics, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Most people aren't aware they can trigger allergy-like symptoms and serious infections such as pneumonia, according to Manal Mohammed, a lecturer in microbiology at Westminster University.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Roughly six million people in Britain are thought to take statins and it is estimated that up to 30million people take the life-saving pills in the US.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Britain's National Health Service recorded its worst ever performance in treating patients on emergency wards last month, a blow to Prime Minister Boris Johnson's claim that only his Conservatives can safeguard the cherished institution.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
The provincial government is set to announce wide-ranging regulations on vaping products to help deal with skyrocketing rates among youth.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/British Columbia Source Type: news
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