Picroside II, an iridoid glycoside from Picrorhiza kurroa, suppresses tumor migration, invasion, and angiogenesis in vitro and in vivo

In conclusion, our results demonstrated that PII effectively inhibited the metastasis and angiogenesis of cancer cells both in vitro and in vivo, and thus, might be a novel candidate for cancer therapy.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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Vasculogenic mimicry (VM) is the formation of vascular channels lacking endothelial cells. These channels are lined by tumor cells with cancer stem cell features, positive for periodic acid-Schiff, and negative for CD31 staining. The term VM was introduced by Maniotis et al. (1), who reported this phenomenon in highly aggressive uveal melanomas; since then, VM has been associated with poor prognosis, tumor aggressiveness, metastasis, and drug resistance in several tumors, including breast cancer. It is proposed that VM and angiogenesis (the de novo formation of blood vessels from the established vasculature by endothelial ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractBreast cancer (BC) is the most common malignancy in women with a significant increasing incidence during the reproductive life. However, based on the newest anti-cancer molecular targeting drugs, successful treatments lead to the disease healing particularly in young patients, thus refreshing their motherhood programs. However, as effect of the BC treatment, a premature depletion of the ovarian follicle reserve occurs in more than one-third of patients resulting in permanent infertility. To prevent the cancer treatment-related infertility (CTRI), several options are today utilized. Besides the ovary suppression by ...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b01318
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ).The NPs are based on chitosan (CS) conjugate polymers synthesized with different amounts of the photosensitizer tetraphenylchlorin (TPC). These TPC-CS NPs have high loading capacity and strong drug retention due to π-π stacking interactions between the drugs and the aromatic photosensitizer groups of the polymers. CS polymers with 10% of the side chains containing TPC were found to be optimal in terms of drug loading capacity and NP stability. The TPC-CS NPs loaded with MRT...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research
Publication date: 1 June 2020Source: Chemical Engineering Journal, Volume 389Author(s): Qiaojuan Jia, Zhenzhen Li, Chuanpan Guo, Xiaoyu Huang, Mengmeng Kang, Yingpan Song, Linghao He, Nan Zhou, Minghua Wang, Zhihong Zhang, Guodong Fu, Miao DuAbstractA novel drug nanocarrier system based on bimetallic NiCo Prussian blue analogue (NiCo-PBA) was constructed for targeted anticancer drug delivery and cancer therapy. Rare earth Tb3+ ion was doped in NiCo-PBA to prepare a complex with strong fluorescence performance (represented by NiCo-PBA@Tb3+). The NiCo-PBA@Tb3+ complex was functionalized with poly(ethyleneglycol)- dimethacryl...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 22 February 2020Source: Life SciencesAuthor(s): Maryam Ezzati, Bahman Yousefi, Kobra Velaei, Amin SafaAbstractBreast cancer is one of the well-known malignant tumors among women. In spite of attempts to classifying breast cancer according to its histological and molecular properties, it is almost considered as a dilemma in treatment. Nowadays, public and medical attentions have primary focused on foods with anti-cancer properties to alleviate the cancer problems. Flavonoid components such as Quercetin (Qu) as dietary substances with high attention of ordinary people might provide potentia...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Andrea BUSNELLI, Amerigo VITAGLIANO, Laura MENSI, Stefano ACERBONI, Alessandro BULFONI, Francesca FILIPPI, Edgardo SOMIGLIANAAbstractSeveral epidemiological studies investigated the effects of cancer therapies on fertility. However, conflicting data have been reported.The present systematic review and meta-analysis aims to determine the chances of childbirth in women survived from different types of cancer.We systematically searched Pubmed, MEDLINE, Embase and Scopus, from database inception to July 17, 2019, for published ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
(Wiley) For women with hormone receptor-positive breast cancer, long-term endocrine therapy can greatly reduce the risk of recurrence. Many women, especially those in underserved populations, do not continue treatment, however. A new Psycho-Oncology study uncovers some of the factors that may be involved.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Abstract In this review we summarize the impact of the various modalities of breast cancer therapy coupled with intrinsic patient factors on incidence of subsequent treatment-induced myelodysplasia and acute myelogenous leukemia (t-MDS/AML). It is clear that risk is increased for patients treated with radiation and chemotherapy at younger ages. Radiation is associated with modest risk, whereas chemotherapy, particularly the combination of an alkylating agent and an anthracycline, carries higher risk and radiation and chemotherapy combined increase the risk markedly. Recently, treatment with granulocyte colony-stim...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
Publication date: Available online 16 February 2020Source: Life SciencesAuthor(s): Shima Bastaki, Mahzad Irandoust, Armin Ahmadi, Mohammad Hojjat-Farsangi, Patrick Ambrose, Shahin Hallaj, Mahdi Edalati Fathabad, Ghasem Ghalamfarsa, Gholamreza Azizi, Mehdi Yousefi, Hengameh Chalajour, Farhad Jadidi-NiaraghAbstractAlthough both the incidence and the mortality rate of breast cancer is rising, there is no potent and practical option for the treatment of these patients, particularly in advanced stages. One of the most critical challenges for treatment is the presence of complicated and extensive tumor escape mechanisms in the t...
Source: Life Sciences - Category: Biology Source Type: research
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