Dual roles of glutathione S-transferase mu 1 in the development and metastasis of hepatocellular carcinoma

ConclusionGSTM1 down-regulation may partially account for ROS-mediated oxidative damage and HCC carcinogenesis. GSTM1 also regulates tumor progression by disrupting the ROS-TP53 axis in HCC cells with different genetic backgrounds.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research