Evaluation of Phenolic Bioactive-Linked Anti-Hyperglycemic and Helicobacter pylori Inhibitory Activities of Asian Basil (Ocimum spp.) Varieties

Publication date: Available online 9 October 2019Source: Journal of Herbal MedicineAuthor(s): Lokesh K Mishra, Dipayan Sarkar, Rao Mentreddy, Kalidas ShettyAbstractBasil (Ocimum spp.) is an important herb from the Lamiaceae family with a long history of use in traditional medicine and food applications. Thus, targeting basil varieties for developing herbal medicines against non-communicable chronic diseases (NCDs) such as type 2 diabetes has significant merit. The aim of this study was to screen Asian basil varieties with therapeutic potential for type 2 diabetes targeting relevant phenolic bioactive-linked antioxidant, anti-hyperglycemic, and antimicrobial properties and was compared with a high phenolic and high antioxidant mint species (Mentha arvensis). Aqueous and ethanol (12%) extracts of 8 different varieties of Asian basil were analyzed for total soluble phenolic (TSP) content, phenolic acid profiles, total antioxidant activity (TA), α-amylase, and α-glucosidase enzyme inhibitory activities and inhibition of ulcer-causing bacteria, Helicobacter pylori using in vitro assay models. The highest TSP content was observed in mint and all basil varieties were compared to this standard. High TA, and α-glucosidase enzyme inhibitory activity were observed in targeted varieties of Indian basils. Major phenolic acids found were rosmarinic, ellagic, benzoic, and gallic acids, which may potentially contribute to health benefits such as antioxidant and anti-hypergl...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research

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Publication date: Available online 15 November 2019Source: Trends in Food Science &TechnologyAuthor(s): Ryoiti KiyamaAbstractBackgroundGreen tea is produced from the tea plant Camellia sinensis without fermentation, and contains characteristic constituents, which are associated with health-promoting effects such as physiological, immunological, neurological and psychological effects, and protective effects against diseases, such as cancer, cardiovascular diseases and diabetes. Catechins, such as catechin, epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate, and other green tea consti...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 15 November 2019Source: Biotechnology ReportsAuthor(s): Pradeep Kumar, Balwant Singh, Vikram Thakur, Abhishek Thakur, Nandita Thakur, Deepak Pandey, Duni ChandAbstractTaxol® (generic name Paclitaxel) is a chemotherapeutic drug, effective against head, neck, breast, lung, bladder, ovary, and cervix cancers. Rising demands in chemotherapy and limited supply of natural taxol have ultimately increased the cost of the drug. Semi synthesis using taxol precursors is not able to meet the global supply and has intensified the need to find alternative ways of taxol production. In the present st...
Source: Biotechnology Reports - Category: Biotechnology Source Type: research
Publication date: November 2019Source: Saudi Journal of Biological Sciences, Volume 26, Issue 7Author(s): Priyanka Verma, Ajar Nath Yadav, Kazy Sufia Khannam, Shashank Mishra, Sanjay Kumar, Anil Kumar Saxena, Archna SumanAbstractThe biodiversity of wheat associated bacteria was deciphered from the peninsular zone of India. A total of 264 isolated bacteria were analyzed through amplified ribosomal DNA restriction analysis (ARDRA, using three restriction enzymes Alu I, Msp I and Hae III, which led to the clustering of these isolates into 12–16 groups for the different sites at>75% similarity index, adding up to 70 g...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: November 2019Source: Saudi Journal of Biological Sciences, Volume 26, Issue 7Author(s): Shalini Saggu, Hasibur Rehman, Al Thbiani Aziz, Fahad M.A. Alzeibr, Atif Abdulwahab A. Oyouni, Nahla Zidan, Chellasamy Panneerselvam, Subrata TrivediAbstractCadmium is among the toxic and hazardous metal widely dispersed in the environment in high levels. Current studies have provided new insights into antioxidant properties of bioflavonoid which have emerged as probable therapeutic and nutraceutical agents. The present study is geared to investigate the possible role of Cymbopogon schoenanthus (L.) Spreng. (or Ethkher...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
A 59-year-old man with type 2 diabetes presented at our hospital because of epigastric pain and nausea. He had a history of gastric ulcers and had undergone Helicobacter pylori eradication therapy 2 years before presenting at  our hospital. EGD showed only ulcer scars in the stomach (A). Esomeprazole (20 mg/day), the proton pump inhibitor taken by the patient for GERD, was changed to a potassium-competitive acid blocker (vonoprazan, 20 mg/day).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: At the focal point Source Type: research
Abstract Helicobacter pylori is one of the most common human pathogens that can cause gastrointestinal (GI) disorders, including simple gastritis, gastric ulcer, and malignant gastritis. In some cases, such as immunodeficiency and underlying diseases, it can be problematic as opportunistic infections. Diabetes mellitus (type 2) (T2DM) is one of the H. pylori underlying diseases. Since GI problems are observed in diabetic patients, it is necessary to treat H. pylori infection. In this review, we aimed to evaluate the possible relationship between H. pylori and T2DM according to epidemiological surveys of 70 studies...
Source: Biomed Res - Category: Research Authors: Tags: Adv Biomed Res Source Type: research
Lactobacillus reuteri is an endlessly fascinating microorganism that can inhabit the human intestinal tract. This is the bacterial species we have been cultivating in our L. reuteri yogurt using the two strains, ATCC PTA 6475 and DSM 17938, that boost hypothalamic release of oxytocin and thereby smooths skin wrinkles, accelerates healing, turns off appetite, builds muscle, preserves bone density, and yields other spectacularly beneficial effects. Animals such as pigs, mice, dogs, sheep, cows, and birds have abundant quantities of L. reuteri (of various strains) in their guts, but only 4% of modern humans hav...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune lactobacillus probiotic reuteri undoctored Weight Loss wheat belly yogurt Source Type: blogs
BackgroundPancreatic ductal adenocarcinoma (PDAC) is usually diagnosed in late adulthood; therefore, many patients suffer or have suffered from other diseases. Identifying disease patterns associated with PDAC risk may enable a better characterization of high-risk patients.MethodsMultimorbidity patterns (MPs) were assessed from 17 self-reported conditions using hierarchical clustering, principal component, and factor analyses in 1705 PDAC cases and 1084 controls from a European population. Their association with PDAC was evaluated using adjusted logistic regression models. Time since diagnosis of morbidities to PDAC diagno...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Upper gastrointestinal bleeding (UGIB)/ peptic ulcer bleeding (PUB) remains to be one of the most common gastrointestinal emergencies with Helicobacter pylori infection as a risk factor. The link between H.  pylori and type 2 diabetes mellitus (T2DM) remains controversial, as some studies indicate higher prevalence of infection in diabetics. Hence, the possibility for a causal relationship between H. pylori and diabetes is an intriguing issue deserving discussion.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Abstract: Vagus nerve may play a role in serum glucose modulation. The complicated peptic ulcer patients (with perforation or/and bleeding) who received surgical procedures with or without vagotomy provided 2 patient populations for studying the impact of vagus nerve integrity. We assessed the risk of developing type 2 diabetes in peptic ulcer patients without and with complications by surgical treatment received in a retrospective population study using the National Health Insurance database in Taiwan. A cohort of 163,385 patients with peptic ulcer and without Helicobacter pylori infection in 2000 to 2003 was established...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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