Evaluation of Phenolic Bioactive-Linked Anti-Hyperglycemic and Helicobacter pylori Inhibitory Activities of Asian Basil (Ocimum spp.) Varieties

Publication date: Available online 9 October 2019Source: Journal of Herbal MedicineAuthor(s): Lokesh K Mishra, Dipayan Sarkar, Rao Mentreddy, Kalidas ShettyAbstractBasil (Ocimum spp.) is an important herb from the Lamiaceae family with a long history of use in traditional medicine and food applications. Thus, targeting basil varieties for developing herbal medicines against non-communicable chronic diseases (NCDs) such as type 2 diabetes has significant merit. The aim of this study was to screen Asian basil varieties with therapeutic potential for type 2 diabetes targeting relevant phenolic bioactive-linked antioxidant, anti-hyperglycemic, and antimicrobial properties and was compared with a high phenolic and high antioxidant mint species (Mentha arvensis). Aqueous and ethanol (12%) extracts of 8 different varieties of Asian basil were analyzed for total soluble phenolic (TSP) content, phenolic acid profiles, total antioxidant activity (TA), α-amylase, and α-glucosidase enzyme inhibitory activities and inhibition of ulcer-causing bacteria, Helicobacter pylori using in vitro assay models. The highest TSP content was observed in mint and all basil varieties were compared to this standard. High TA, and α-glucosidase enzyme inhibitory activity were observed in targeted varieties of Indian basils. Major phenolic acids found were rosmarinic, ellagic, benzoic, and gallic acids, which may potentially contribute to health benefits such as antioxidant and anti-hyperglycemic properti...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research