Reversible Mitochondrial Fragmentation in iPSC-Derived Cardiomyocytes from Children with DCMA, a Mitochondrial Cardiomyopathy

ConclusionsWe describe a unique and novel cellular model that provides insight into the mitochondrial abnormalities present in DCMA and identifies SS-31 as a potential therapeutic for this devastating disease.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research

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Publication date: January 2020Source: The Annals of Thoracic Surgery, Volume 109, Issue 1Author(s): Muhammad Aftab, T. Brett Reece, Lars G. Svensson
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionFindings support the cross-cultural relevance of SDT while at the same time highlighting important cultural variations such as greater importance of competence support in the West, suggesting the need to be cognizant of both cross-cultural universality and variability in motivational theorizing.
Source: Journal of Adolescence - Category: Child Development Source Type: research
Canadian Journal of Zoology, e-First Articles. Senescence is the age-specific decline in fitness of adult organisms principally associated with a decline in survival rate (actuarial senescence) and fecundity (reproductive senescence). Although common in natural populations of many taxa, there are few examples in fishes. A recent study found age-specific increases in the relative frequency of macroscopically non-reproductive Atlantic herring (Clupea harengus Linnaeus, 1758), consistent with reproductive senescence in a number of Canadian populations. However, a non-adaptive explanation for these patterns, unrelated to senes...
Source: Canadian Journal of Zoology - Category: Zoology Authors: Source Type: research
Canadian Journal of Zoology, e-First Articles. Human-mediated disturbances can lead to novel environmental features that can affect native biota beyond simple habitat loss. In boreal forests of western Canada, linear features (LFs; e.g., pipelines, seismic lines, and roads) are known to alter behaviour, movements, and interactions among species. Understanding LF impacts on native species has therefore been a management priority. Here, we investigate how LFs affect the spatial behaviour of wood bison (Bison bison athabascae Rhoads, 1898), which are designated as “threatened” in Canada. Using data collected from ...
Source: Canadian Journal of Zoology - Category: Zoology Authors: Source Type: research
We present an unusual case of indapamide-induced hyponatremia and hypokalemia complicated by cardiac arrhythmia. The adverse drug reaction was reversible and non-life-threatening, but this case serves as a reminder that careful evaluation and constant monitoring are necessary when prescribing diuretics. PMID: 31827736 [PubMed]
Source: American Family Physician - Category: Primary Care Authors: Tags: Malays Fam Physician Source Type: research
Conclusions: The in vitro study revealed that the duration of hypoxia is crucial for osteogenic differentiation of precursor cells. The results from both the in vitro and in vivo studies show the role of STAT3 signaling in hypoxia-induced osteogenic differentiation of precursor cells and bone defect healing. PMID: 31827540 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Tags: Cell Mol Biol Lett Source Type: research
Publication date: Available online 20 November 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Cláudia M. Deus, Susana P. Pereira, Teresa Cunha-Oliveira, Francisco B. Pereira, Nuno Raimundo, Paulo J. OliveiraAbstractParkinson's Disease (PD) is characterized by dopaminergic neurodegeneration in the substantia nigra. The exact mechanism by which dopaminergic neurodegeneration occurs is still unknown; however, mitochondrial dysfunction has long been implicated in PD pathogenesis. To investigate the sub-cellular events that lead to disease progression and to develop personalized in...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 13 December 2019Source: Aquatic ToxicologyAuthor(s): Feng Lin, Heather L. Osachoff, Christopher J. KennedyAbstractCurrent and proposed transcontinental pipelines for the transport of diluted bitumen (dilbit) from the Canadian oil sands traverse the coastal watersheds of British Columbia, habitat essential to Pacific salmonids. To determine the potential risks posed to these keystone species, juvenile sockeye (Oncorhynchus nerka; 1+ parr) were acutely (24 - 96 h) or subchronically (21 - 42 d) exposed to 4 concentrations of the water-soluble fraction (WSF) of unweathered Cold Lake Bl...
Source: Aquatic Toxicology - Category: Toxicology Source Type: research
Abstract Friedreich's ataxia (FRDA), which occurs in 1/50000 live births, is the most prevalent inherited neuromuscular disorder. Nearly all FRDA patients develop cardiomyopathy at some point in their lives. The clinical manifestations of FRDA include ataxia of the limbs and trunk, dysarthria, diabetes mellitus, and cardiac diseases. However, the broad clinical spectrum makes FRDA difficult to identify. The diagnosis of FRDA is based on the presence of suspicious clinical factors, the use of the Harding criteria and, more recently, the use of genetic testing for identifying the expansion of a triplet nucleotide se...
Source: World Journal of Cardiology - Category: Cardiology Authors: Tags: World J Cardiol Source Type: research
Publication date: Available online 26 August 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Jan Dudek, Magnus Hartmann, Peter RehlingAbstractMitochondria play an essential role in the energy metabolism of the heart. Many of the essential functions are associated with mitochondrial membranes and oxidative phosphorylation driven by the respiratory chain. Mitochondrial membranes are unique in the cell as they contain the phospholipid cardiolipin. The important role of cardiolipin in cardiovascular health is highlighted by several cardiac diseases, in which cardiolipin plays a fundamenta...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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