Development of a quantitative statistical analysis system for double inversion recovery (DIR) MRI: A preliminary clinical study.

Development of a quantitative statistical analysis system for double inversion recovery (DIR) MRI: A preliminary clinical study. Technol Health Care. 2019 Aug 29;: Authors: Hayashi N, Sato Y, Maruyama T, Shimoyama Y, Motegi S, Ujita K, Kumasaka S, Ogura A, Ogura T, Tsushima Y Abstract BACKGROUND: Gray matter (GM) imaging is important in the investigation of many neurological diseases, including schizophrenia, multiple sclerosis, stroke, Alzheimer's disease, tuberous sclerosis, and epilepsy, which are all associated with changes in cortical GM. OBJECTIVE: The aim of this study was to develop a quantitative statistical analysis system for double inversion recovery (DIR) MRI and to evaluate the new system using preliminary clinical data. METHODS: The study population comprised of 10 healthy volunteers and six patients with or without brain degeneration. A quantitative statistical analysis system for DIR images was developed using the following steps: 1) brain spatial normalization, 2) mean and standard deviation (SD) map creation, and 3) Z-score map creation. To evaluate the new voxel-based morphometry system, Z-scores of lesions in patients with brain degeneration were measured and then compared with Z-scores of normal regions. RESULTS: All DIR images were adequately spatially normalized to Montreal Neurological Institute MNI coordinate. Lesions in each patient were indicated by high Z-score values on a Z-score map, which were significantly ...
Source: Technology and Health Care - Category: Medical Devices Authors: Tags: Technol Health Care Source Type: research

Related Links:

Psychiatric Services, Ahead of Print.
Source: Psychiatric Services - Category: Psychiatry Authors: Source Type: research
Psychiatric Services, Ahead of Print.
Source: Psychiatric Services - Category: Psychiatry Authors: Source Type: research
Psychiatric Services, Ahead of Print.
Source: Psychiatric Services - Category: Psychiatry Authors: Source Type: research
This article aims to describe and understand the developmental relationships between intestinal microbiota and the risk of developing schizophrenia.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Publication date: Available online 9 December 2019Source: NeuroImageAuthor(s): Robert A. Brown, Dumitru Fetco, Robert Fratila, Giulia Fadda, Shangge Jiang, Nuha M. Alkhawajah, E. Ann Yeh, Brenda Banwell, Amit Bar-Or, Douglas L. Arnold, Canadian Pediatric Demyelinating Disease NetworkAbstractIn conventional non-quantitative magnetic resonance imaging, image contrast is consistent within images, but absolute intensity can vary arbitrarily between scans. For quantitative analysis of intensity data, images are typically normalized to a consistent reference. The most convenient reference is a tissue that is always present in th...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 9 December 2019Source: Progress in Lipid ResearchAuthor(s): M.I. McDermott, Y. Wang, M.J.O. Wakelam, V.A. BankaitisAbstractDespite being discovered over 60 years ago, the precise role of Phospholipase D (PLD) is still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of glycerophospholipids producing phosphatidic acid and the free headgroup. PLD family members are found in organisms ranging from viruses, and bacteria to plants, and mammals, and they display a range of substrate specificities, are regulated by a diverse range of molecules, and have been imp...
Source: Progress in Lipid Research - Category: Lipidology Source Type: research
This study provides an important strategy in learning the cellular processes that are highly associated with intracellular biothiol level.
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Conclusion: Surakka's equation 1, with the prediction approach, was found to be the most accurate for imputing values when fatigue was not reached during a sustained knee isometric fatigability test in RYR1-RM. Furthermore, when used to assess fatigability-based disease stability, local muscle fatigability, in this RYR1-RM population remained stable.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, human multiple sclerosis and mice brain samples were analyzed through mass spectrometry as well as histological and immunoblot techniques, which demonstrated that iron deposition is associated with increased levels of nuclear prelamin A recognition factor (NARF). NARF is a protein associated with the mitochondria which has also been linked to mitochondrial defects in multiple sclerosis. We report NARF to be associated in multiple sclerosis pathology and aberrant iron deposition.
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
AbstractChronic neuroinflammation is strongly associated with AD and altered peripheral and central levels of chemokines and cytokines have been frequently described in those with AD. Given the increasing evidence of ethnicity-related differences in AD, it was of interest to determine if those altered chemokine and cytokine levels are ethnicity-related. Because African Americans exhibit a higher incidence of AD and increased symptom severity, we explored chemokine and cytokine concentrations in post-mortem brain tissue from the BA21 region of African Americans and Caucasians with AD using multiplex assays. IL-1 β, MIG...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
More News: Alzheimer's | Brain | Epilepsy | Health Management | Medical Devices | Multiple Sclerosis | Neurology | Schizophrenia | Statistics | Stroke | Study | Tuberous Sclerosis