Development of a quantitative statistical analysis system for double inversion recovery (DIR) MRI: A preliminary clinical study.

Development of a quantitative statistical analysis system for double inversion recovery (DIR) MRI: A preliminary clinical study. Technol Health Care. 2019 Aug 29;: Authors: Hayashi N, Sato Y, Maruyama T, Shimoyama Y, Motegi S, Ujita K, Kumasaka S, Ogura A, Ogura T, Tsushima Y Abstract BACKGROUND: Gray matter (GM) imaging is important in the investigation of many neurological diseases, including schizophrenia, multiple sclerosis, stroke, Alzheimer's disease, tuberous sclerosis, and epilepsy, which are all associated with changes in cortical GM. OBJECTIVE: The aim of this study was to develop a quantitative statistical analysis system for double inversion recovery (DIR) MRI and to evaluate the new system using preliminary clinical data. METHODS: The study population comprised of 10 healthy volunteers and six patients with or without brain degeneration. A quantitative statistical analysis system for DIR images was developed using the following steps: 1) brain spatial normalization, 2) mean and standard deviation (SD) map creation, and 3) Z-score map creation. To evaluate the new voxel-based morphometry system, Z-scores of lesions in patients with brain degeneration were measured and then compared with Z-scores of normal regions. RESULTS: All DIR images were adequately spatially normalized to Montreal Neurological Institute MNI coordinate. Lesions in each patient were indicated by high Z-score values on a Z-score map, which were significantly ...
Source: Technology and Health Care - Category: Medical Devices Authors: Tags: Technol Health Care Source Type: research

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