Genotype Imputation to Increase Sample Size in Pedigreed Populations

Genotype imputation is a cost-effective way to increase the power of genomic selection or genome-wide association studies. While several genotype imputation algorithms are available, this chapter focuses on a heuristic algorithm, as implemented in the AlphaImpute software. This algorithm combines long-range phasing, haplotype library imputation, and segregation analysis and it is specifically designed to work with pedigreed populations.
Source: Springer protocols feed by Bioinformatics - Category: Bioinformatics Source Type: news