Changes in Depressive Symptoms at Two-Week Treatment Mark May Predict 12-Week Remission Outcomes

Whether patients with major depressive disorder show improvement (or lack thereof) at the end of their second week on an antidepressant medication may predict whether they will ultimately achieve remission at the end of 12 weeks, astudy published inPsychiatric Research&Clinical Practice found.“For any antidepressant medication trial, it is important to identify as early as possible whether the patient is likely to achieve remission …,” wrote Paul B. Hicks, M.D., Ph.D., of Texas A&M College of Medicine and colleagues. “The present study bolsters the proposed use of the lack of early improvement as a predictor of failure to achieve remission with the current medication.”The researchers conducted a secondary analysis of data from the Veterans Affairs Augmentation and Switching Treatments for Improving Depression Outcomes (VAST-D) study, which involved 1,552 veterans aged 18 and older whose major depressive disorder was unresponsive to at least one course of antidepressant treatment. The study participants were randomly assigned to one of three medication treatment groups: augmentation with bupropion sustained release, augmentation with aripiprazole, or switch to a different antidepressant. The dosage remained relatively constant throughout the trial, though the researchers allowed adjustments to doses as early as the end of the first week. The researchers evaluated participants at baseline and at the end of weeks 1, 2, 4, 6, 8, 10, and 12.Early...
Source: Psychiatr News - Category: Psychiatry Tags: antidepressants bupropion depression early improvement Paul Hicks predictive values Psychiatric Research & Clinical Practice QIDS-C remission VAST-D Source Type: research

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Publication date: Available online 14 November 2019Source: The Lancet PsychiatryAuthor(s): Deborah M Caldwell, Sarah R Davies, Sarah E Hetrick, Jennifer C Palmer, Paola Caro, José A López-López, David Gunnell, Judi Kidger, James Thomas, Clare French, Emily Stockings, Rona Campbell, Nicky J WeltonSummaryBackgroundRates of anxiety and depression are increasing among children and young people. Recent policies have focused on primary prevention of mental disorders in children and young people, with schools at the forefront of implementation. There is limited information for the comparative effectiveness of...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Anxiety disorders in adolescence have been associated with several psychiatric outcomes. We sought to describe the prospective relationship between various levels of adolescent anxiety and psychiatric diagnose...
Source: BMC Psychiatry - Category: Psychiatry Authors: Tags: Research article Source Type: research
The presence of comorbid anxiety symptoms does not appear to predict the likelihood that older patients with major depressive disorder (MDD) will respond to the antidepressant venlafaxine, according to astudy inDepression&Anxiety.“[R]emission of depression was just as likely in more and less anxious participants,” Yasmina M. Saade, M.D., of Washington University in St. Louis and colleagues wrote.Previous studies show that older depressed adults with comorbid anxiety often have more severe depression symptoms and cognitive decline and are at greater risk of suicide compared with older depressed adults withou...
Source: Psychiatr News - Category: Psychiatry Tags: anxiety depression & IRL ‐GRey study MADRS MDD older adults suicide ideation Venlafaxine Yasmina M. Saade Source Type: research
CONCLUSIONS: Co-occurring psychotic experiences indicate greater public mental health burden, suggesting psychotic experiences could be a marker for future preventive strategies improving public mental health. PMID: 31713511 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
ConclusionsA history of MST is common among older women veterans and associated with a range of medical and mental health diagnoses. These findings call attention to the need for additional research in this understudied population, and the importance of trauma-informed care approaches for women across the lifespan.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
The swirl of moving away from home for the first time, making new friends, and mastering higher level academics is tough enough for anyone, but young adults who must make this transition or return to classes after losing a parent, sibling, friend, or significant other to suicide are being asked to tackle new surroundings and heavy course loads at the worst possible time. Dr. Ann Phillips, who worked in the counseling field for over 40 years, shared how the University of West Georgia (UWG) in Carrollton, Georgia, helps students, faculty, and parents cope. The mission of UWG’s Prevent Program is to prevent suicides fro...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: College Grief and Loss Suicide Depression grieving Survivors Guilt Source Type: blogs
OBJECTIVE: The purpose of this study was to examine the influence of comorbid anxiety symptoms on antidepressant treatment remission in older adults with major depressive disorder (MDD). METHOD: In this multisite clinical trial, 468 older adults ag...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
The suicide rate has been rising in the US over the last 16 years. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Suicide subscribers-only Source Type: blogs
CONCLUSION: A three-factor GHQ-12 model (anhedonia/sleep disturbances; social performance and Loss of confidence) is useful as a psychological distress assessment tool among Nigerian adolescents. PMID: 31684713 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
CONCLUSIONS: Findings indicate most of the sample populated an 'improvers' class for both depression and anxiety. Pre-treatment variables identified as predictive of poor treatment response may need to be considered by practitioners in potential triage referral decision policies, supporting cost-effective and efficient services. Further research around predictors of clinical outcome is recommended. PRACTITIONER POINTS: Most of the sample belonged to an 'improvers' class. Several pre-treatment variables predicted poor treatment response (unemployment, suicide risk, neglect, medication, previous or concurrent treatments...
Source: The British Journal of Clinical Psychology - Category: Psychiatry & Psychology Authors: Tags: Br J Clin Psychol Source Type: research
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