“Anatomical mechanism of ideation, association and attention” 1895 and “Certain points in neurological histophysiology” 1896: Cajal’s conjectures, then and now
Publication date: Available online 9 October 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Elena I. Antonakou, Lazaros C. TriarhouAbstractThe purpose of this article is two-fold: first, to preserve, in updated English translations, two theoretical papers written by Santiago Ramón y Cajal (1852–1934) in 1895 and 1896 under the titles, “Conjectures on the anatomical mechanism of ideation, association and attention” and “Conjectural interpretations of certain points in neurological histophysiology”; and second, to set some of the ideas proposed by Cajal in a modern perspective. In his “Conjectures,” Cajal ventured to explain the mechanisms of perception, association and attention in cellular terms. He introduced the term “impression unit,” which would propagate, leading to conscious act via an “avalanche of conduction.” Additionally, he attributed mental repose and sleep to morphological variations of neuroglia; at times of relaxation, astrocytes would grow appendices that penetrated among nerve cell connections and blocked the conduction of the “nervous current”; in energetic contraction, such glial “pseudopodia” would shrink, allowing neuronal processes to come into contact again. In the sequel to the “Conjectures,” Cajal presented strong arguments defending the neuron theory against the reticular theory. Moreover, he discussed the functional differentiation of...
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Publication date: Available online 10 October 2020Source: IJC Heart &VasculatureAuthor(s): Dominik Linz, Jeroen Hendriks
Background: Obesity is strongly associated with both Blount disease and obstructive sleep apnea (OSA). Obesity increases risks for anesthetic and postoperative complications, and OSA can further exacerbate these risks. Since children with Blount disease might have both conditions, we sought to determine the perioperative complications and the prevalence of OSA among these children. Methods: Patients younger than 18 years undergoing corrective surgery for Blount disease were identified from 2 sources as follows: a retrospective review of records at a single institution and querying of the Kids’ Inpatient Database...
Publication date: Available online 9 October 2020Source: Molecular MetabolismAuthor(s): Xiao Tan, Lieve van Egmond, Jonathan Cedernaes, Christian Benedict
Date: Thursday, 10 08, 2020; Speaker: Craig Heller, Ph.D., Stanford University; Sigrid Veasey, M.D., University of Pennsylvania; Colleen McClung, Ph.D., University of Pittsburgh; Gary Aston-Jones, Ph.D., Rutgers University; Thomas Kilduff, Ph.D., SRI International, ; Ryan Logan, Ph.D., University of Pittsburg; Carol Everson, Ph.D., Medical College of Wisconsin; Xiaoke Chen, Ph.D., Stanford University ; Michael T. Smith, Ph.D., Johns Hopkins University; Henry Yaggi, M.D., Yale University ; Andre Huhn, Ph.D., Johns Hopkins University ; Mark Greenwald, Ph.D., Wayne State; Scott Bunce, Ph.D., Penn State University ; Johanna El...
DR MICHAEL MOSLEY: Now, lots of people have a late-night tipple because they believe that alcohol helps them sleep better. But recent research shows quite clearly that this is a myth.
Conclusions: Bioinformatics analysis is a useful tool to explore the mechanism and pathogenesis of PHN. The identified hub genes may participate in the onset and development of PHN and serve as therapeutic targets. PMID: 33029266 [PubMed - in process]
Conditions: Obstructive Sleep Apnea of Adult; Periodontal Diseases; Periodontal Pocket; Periodontal Attachment Loss Intervention: Sponsor: I.M. Sechenov First Moscow State Medical University Not yet recruiting
Condition: Post-traumatic Stress Disorder Interventions: Behavioral: Sleep recording; Behavioral: Cognitive tasks; Other: Questionnaires Sponsor: Direction Centrale du Service de Santé des Armées Not yet recruiting
Conclusion: High levels of plasma melatonin during the overnight period of intensive care cohort patients did not improve sleep nor decreased the prevalence of delirium. This trial is registered with Anzctr.org.au/ACTRN12620000661976.aspx. PMID: 33029397 [PubMed]