Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions.

Conclusions: The combination of quantitative intravital imaging with deep transcriptomes identified four subsets of vascular macrophages in atherosclerosis that have unique transcriptomic profiles. Our data are the first to link vascular macrophage transcriptomes to their in vivo migratory function. Future work on the functional significance of the change in gene expression and motility characteristics will be needed to fully understand how these subsets contribute to disease progression. PMID: 31594470 [PubMed - as supplied by publisher]
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research