Evaluation of bioactive compounds-loaded chitosan films as a novel and potential diabetic wound dressing material

Publication date: Available online 9 October 2019Source: Reactive and Functional PolymersAuthor(s): Liora Colobatiu, Alexandru Gavan, Adrian-Valentin Potarniche, Vasile Rus, Zorita Diaconeasa, Andrei Mocan, Ioan Tomuta, Simona Mirel, Marian MihaiuAbstractDelayed wound healing is a major complication of diabetes and the medical treatment of such wounds still remains a challenge. Among the modern wound dressings, film dressings are considered to be one of the major advances in wound management. In the current study, the feasibility of using a previously developed and optimized bioactive compounds-loaded chitosan film formulation as a functional wound dressing material for diabetic wounds was investigated. The antioxidant capacity, as well as the effect of the chitosan films on cell viability was assessed in vitro. Furthermore, the in vivo performance of the films was further evaluated, by using a streptozotocin-induced diabetic rat model. The chitosan film formulation provided a beneficial moist wound environment, reducing the risk of dehydration and favouring the closure of the wounds. Also, it exhibited good antioxidant activity, as well as a proliferative effect and adequate biocompatibility. The in vivo evaluation of the bioactive compounds-loaded chitosan film formulation confirmed that the biofilm stimulated wound contraction and accelerated the wound healing process. The results strongly support that the above mentioned chitosan film seems to be a promising formulation, ...
Source: Reactive and Functional Polymers - Category: Chemistry Source Type: research