Invasive pulmonary aspergillosis in critically ill patients with hematological malignancies

AbstractPurposeInvasive pulmonary aspergillosis (IPA) is a dreadful event in patients with hematological malignancies (HM). Recent advances have standardized diagnostic, prophylactic and curative therapeutic strategies. We sought to assess whether these advances actually translate into improved survival in critically ill patients with acute respiratory failure and IPA.MethodsThis was a retrospective, multicenter study. Adult patients with HM, IPA, admitted to the ICU for acute respiratory failure over a 20-year period (January 1998 –December 2017) were included. A cox regression model was used to identify variables independently associated with day-90 survival.ResultsOverall, 219 patients were included [138 (63%) men, median age 55 (IQR 44 –64)]. Acute myeloid leukemia (30.1%) and non-Hodgkin lymphoma (22.8%) were the most frequent malignancies, and 53 (24.2%) were allogeneic stem cell recipients. Day-1 SOFA score was 9 [7–12]. Most patients presented with probable IPA, whereas 15 (7%) underwent lung biopsies or pleurocentesis and met criteria for proven IPA. Overall ICU and day-90 mortality were, respectively, 58.4% and 75.2% (80.4% if invasive mechanical ventilation) without any significant improvement over time. By multivariable analysis adjusted on day-1 SOFA score and ventilation strategies, voriconazole use (HR 0.49, CI 95 0.34 –0.73,p 
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research

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ConclusionInguinal lymphocele that is not reabsorbed or does not resolve with conservative treatment should be surgically treated. Lymphocele excision with ligation of lymphatic vessels, followed by negative pressure wound therapy appears to be a safe and effective approach.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Authors: Grobbelaar C, Ford AM Abstract Acute lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Although the overall survival of children with ALL is now more than 90%, leukaemia remains one of the leading causes of death from disease. In developed countries, the overall survival of patients with ALL has increased to more than 80%; however, those children cured from ALL still show a significant risk of short- and long-term complications as a consequence of their treatment. Accordingly, there is a need not only to develop new methods of diagnosis and prognosis but also to provide patients with le...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
Authors: Sheng X, Tian C, Liu L, Wang L, Ye X, Li J, Zeng M, Liu L Abstract In the original publication the labelling of Figure 1D, Y-axis is incorrectly published. The correct labeling should be read as Fragilis+/SSEA1+ and the correct figure is provided in this correction. PMID: 31741146 [PubMed - as supplied by publisher]
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
Conclusions: IENFD measurement in postmortem skin is feasible and may be used to study the epidemiology of SFN.
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Original Article Source Type: research
This installment of what is in the literature is on amyotrophic lateral sclerosis (ALS). The pathophysiology of ALS remains open and the role of genes, a foothold into pathophysiology, but there are>22 genes identified, and the mechanisms are not known for any. Despite the lack of a firm understanding of pathophysiology, drug trials continue based on possible mechanisms, but no new drugs beyond riluzole and edaravone have been positive in phase 3 trials. There are a number of formal stem cell trials underway, and the results of a phase 2 trial are described. Major efforts to make trials more sensitive are being consider...
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Review Article Source Type: research
No abstract available
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Letters to the Editor Source Type: research
We certainly appreciate the thoughtful comments of Dr  Lisotti and Dr Fusaroli1 on our article2 regarding the efficacy of contrast-enhanced EUS (CE-EUS) for differential diagnosis of lymphadenopathy. It should be emphasized, and as indicated in the article, we believe that the diagnostic capability of CE-EUS for lymphadenopathy is significantly improv ed by combining qualitative with quantitative analysis. In our study, because almost half of the malignant lymphoma showed a homogeneous enhancement pattern on CE-EUS, indicating a benign lesion, the assessment of lymphadenopathy using qualitative CE-EUS alone had limite...
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Condition:   Rheumatoid Arthritis Intervention:   Biological: autologous adipose derived stem cells Sponsor:   Celltex Therapeutics Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Inflammatory Bowel Diseases Intervention:   Procedure: Cord Blood Stem Cell Transplantation Sponsors:   Children's Hospital of Fudan University;   Shanghai Children's Hospital;   Children's Hospital Of Soochow University;   Beijing Children's Hospital;   Guangzhou Women and Children's Medical Center;   Shenzhen Children's Hospital;   Wuhan Women and Children's Medical  Center;   Children’s Hospital...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Relapsed and Refractory B Cell Lymphoma;   Non-Hodgkin Lymphoma Intervention:   Biological: CD20 CAR-T Sponsor:   Shanghai Longyao Biotechnology Inc., Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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