Reply to: “Assessment of liver phenotype in adults with severe alpha-1 antitrypsin deficiency (Pi*ZZ genotype)”

We appreciate the interest and comments by Dr. Kumpers1 et al. on our recent work characterizing the clinical and histological findings in patients with severe alpha-1 antitrypsin (AAT) deficiency.2 To that end, we reviewed how the proposed liver stiffness measurements (LSM) ≥7.1 kPa performed in our cohort. Using that cut-off, the prevalence of clinically significant fibrosis defined as stage ≥2 would be 26%, which is remarkably similar to the 23.6% reported by Hamesch et al.3 in a large study that did not include biopsies.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research