Markers of responsiveness to disopyramide in patients with hypertrophic cardiomyopathy

Significant left-ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) may result in symptoms and is associated with adverse outcomes. Although disopyramide can reduce resting gradients, nearly 30% of HCM patients do not respond. We sought to study the clinical and echocardiographic variables associated with disopyramide-induced LVOT-gradient reduction.

Source: International Journal of Cardiology - October 8, 2019 Category: Cardiology Authors: Manhal Habib, Sara Hoss, Beata Bruchal-Garbicz, Raymond H. Chan, Harry Rakowski, Lynne Williams, Arnon Adler Source Type: research