Treatment of cognitive deficits in brain tumour patients: current status and future directions

Purpose of review Increased life expectancy in brain tumour patients had led to the need for strategies that preserve and improve cognitive functioning, as many patients suffer from cognitive deficits. The tumour itself, as well as antitumor treatment including surgery, radiotherapy and chemotherapy, supportive treatment and individual patient factors are associated with cognitive problems. Here, we review the recent literature on approaches that preserve and improve cognitive functioning, including pharmacological agents and rehabilitation programs. Recent findings Minimizing cognitive dysfunction and improving cognitive functioning in brain tumour patients may be achieved both by preserving cognitive functioning during antitumor treatment, including techniques such as awake brain surgery, less invasive radiation therapies such as stereotactic radiotherapy and proton therapy, as well as with interventions including cognitive rehabilitation programmes. Novel rehabilitation programs including computer-based cognitive rehabilitation therapy (CRT) programmes that can be adjusted to the specific patient needs and can be administered at home are promising. Furthermore, personalized/precision medicine approaches to identify patients who are at risk for cognitive decline may facilitate effective treatment strategies in the future. Summary Cognitive functioning has gained greater awareness in the neuro-oncological community, and methods to preserve and improve cognitive funct...
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: BRAIN AND NERVOUS SYSTEM: Edited by Marc Sanson Source Type: research

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Authors: Ferreira LP, Pinheiro CF, Fernandes NA, Ferreira CN PMID: 31730304 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Conclusion: The positive and negative points of the image-based cell models and computergenerated cell models some scientific advices are presented in this work. Generally, the imagebased cell models could offer analytical facts for each state, but they are expensive and timeconsuming; besides, their performance is heavily influenced by deformation techniques. The computer-generated cell model, on the other hand, provides a higher cost of production and simplicity, but its main contribution is the overall performance and accuracy.
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
The objective of this study was to characterize the chemical composition of essential oil derived from A. montana achenes and to investigate its effect on induction of apoptosis and autophagy in human anaplastic astrocytoma MOGGCCM and glioblastoma multiforme T98G cell lines. The chemical composition of essential oil extracted from the achenes was examined with the use of Gas Chromatography–Mass Spectrometry GC-MS. Only 16 components of the essential oil obtained from the achenes of 3-year-old plants and 18 components in the essential oil obtained from the achenes of 4-year-old plants constituted ca. 94.14% and 9...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
AbstractAtypical teratoid/rhabdoid tumor (ATRT) is a highly malignant brain tumor predominantly occurring in infants. Mutations of theSMARCB1 gene are the characteristic genetic lesion. SMARCB1-mutant tumors in adolescents and adults are rare and may show uncommon histopathological and clinical features. Here we report seven SMARCB1-deficient intracranial tumors sharing distinct clinical, histopathological and molecular features. Median age of the four females and three males was 40  years (range 15–61 years). All tumors were located in the pineal region. Histopathologically, these tumors displayed spindled...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
Publication date: Available online 14 November 2019Source: Seminars in Cancer BiologyAuthor(s): Markus David Siegelin, Elisabeth Schneider, Mike-Andrew Westhoff, Christian Rainer Wirtz, Georg Karpel-MasslerAbstractMalignant gliomas are still extremely difficult to treat because complete surgical resection is biologically not feasible due to the invasive nature of the disease and the proximity of tumors to functionally sensitive areas. Moreover, adjuvant therapies are facing a strong therapeutic resistance since the central nervous system is a highly protected environment and the tumor cells display a vast intra-tumoral gen...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
In this study, we investigated the effects of AMPA receptor antagonist perampanel in rat C6 glioma model. In first pilot experiments, perampanel reduced glucose uptake but had no impact of extracellular glutamate level in vitro. To analyze the effects of perampanel in vivo, we injected C6 cells orthotopically into the neocortex of Wistar rats in order to establish a model of glioma-associated epilepsy. Spontaneous recurrent discharges in brain slices were abolished upon perfusion with the AMPA receptor blocker perampanel, supporting the major role of glutamatergic excitation. With respect to the tumor progression, no effec...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
ConclusionThe proposed system focused on classification accuracy of the different types of tumours from the 3D MRI images. This paper solves the issues of binary classification, the processing time, and the issues of overfitting of the data.Graphical abstractAbeer Alsadoon (2019)
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Publication date: December 2019Source: Journal of Clinical Neuroscience, Volume 70Author(s): Ebrahim Najafzadeh, Hossein Ghadiri, Maysam Alimohamadi, Parastoo Farnia, Mohammad Mehrmohammadi, Alireza AhmadianAbstractAccurate margin delineation and safe maximal resection of glioma is one of the most challenging problems of neurosurgery, due to its close resemblance to normal brain parenchyma. However, different intraoperative visualization methods have been used for real-time intraoperative investigation of the borders of the resection cavity, each having advantages and limitations. This preliminary study was designed to sim...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Abstract Glioblastoma (GBM) is the most common and malignant intracranial tumor in adults. Despite continuous improvements in diagnosis and therapeutic method, the prognosis is still far away from expectations. The invasive phenotype of GBM is the main reason for the poor prognosis. Epithelial-mesenchymal transition (EMT) is recognized as a participator in this invasive phenotype. Resveratrol, a natural plant-derived compound, is reported to be able to regulate EMT. In the present study, we used TGF-β1 to induce EMT and aimed to evaluate the effect of resveratrol on EMT and to explore the underline mechanism ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conditions:   Grade 2 Glioma;   Residual Glioma;   Recurrent Glioma Interventions:   Drug: AG-881;   Drug: Matching Placebo Sponsor:   Agios Pharmaceuticals, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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