Gene testing to guide antidepressant treatment: Has its time arrived?

Depressive disorders are among the most common conditions that disrupt lives. Fortunately, medications, psychotherapies, and lifestyle changes are usually successful in treating depression and related disorders, even if symptoms are not entirely eliminated. Sometimes people don’t gain sufficient relief from treatment, or must try several medications before finding one that works well. In an age of exciting advances, including brain imaging and genetic testing, many doctors and patients reasonably hope that new technologies will offer answers. And in fact, for antidepressant choice, several companies sell genetic testing as a means to guide treatment. But do these tests work? Genes, gene testing, and depression Genes determine some of our risk for depression and some of our response to treatment. However, no single gene or small number of genes determines much of either in the general population. And the few genes used in the current commercial test panels do not appear to be the key genes determining risk or response. Some of the genes tested are related to drug metabolism. These genes can affect drug levels in the blood, but generally don’t predict clinical response. Other factors, including age, diet, hormonal state, gut bacteria, and any other concurrently taken drugs, are far more important in determining how a person metabolizes a drug and responds to treatment. Most people with depression improve with careful evaluation of all of these factors, appropriate a...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Anxiety and Depression Health Mental Health Tests and procedures Source Type: blogs

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Conclusion: Natural recovery after TBI may include delayed onset of functional decline or early recovery, followed by progressive deterioration, and is negatively affected by medical comorbidities. Results contribute to the growing evidence that TBI is most appropriately treated as a chronic medical condition complicated by a variety of comorbid conditions.
Source: The Journal of Head Trauma Rehabilitation - Category: Neurology Tags: Original Articles Source Type: research
You're reading The Impact of the Media’s Glamorization of Drug Abuse on Mental Health, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. We often hear about celebrities with addictions from various news outlets. Addiction and mental health issues can affect anyone. In fact, about 19% of all U.S. adults have dealt or are currently dealing with a mental illness, according to a national survey held by SAMHSA in 2017. The Role of Media in Drug Abuse It has been shown that the media contributes to the stigma of m...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: depression internet culture psychology self education self improvement celebrities with addictions celebrity overdoses role of media in drug abuse songs about drugs Source Type: blogs
It’s a Wednesday evening in Brooklyn, NY, and bars are dead. Tea-candle-dotted tables sit empty, waiting for a happy hour rush that isn’t. But tucked away on a side street, hours before its midnight closing time, a bar called Getaway hums with activity. Metal straws clink against ice and cocktail shakers rattle as patrons belly up to the marble bar. A woman fresh out of work reads and nurses a drink at a corner table. An early-thirties couple chats over a pre-dinner beverage, holding hands in the flattering dim lighting. This is New York City’s first permanent booze-free bar, and no one is drinking alcoho...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized public health Source Type: news
    What is schizophrenia? From pop culture’s view to Rachel Star Withers, a diagnosed schizophrenic, view of herself to a leading mental health doctor and professor’s view. What are the actual symptoms? What is the difference between a hallucination and delusion? What is it like to experience one? How do you manage it? How is social media changing the way it is viewed? In this first episode of Inside Schizophrenia, Rachel and co-host Gabe Howard with special guest Dr. Ali Mattu explore this often misrepresented mental illness. Highlights From ‘Schizophrenia’ Episode [00:40] Would you th...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Peer Support Self-Help Source Type: blogs
Yafei Tan1,2, Omer Van den Bergh2, Jiang Qiu1* and Andreas von Leupoldt2* 1Faculty of Psychology, Southwest University, Chongqing, China 2Health Psychology, KU Leuven, Leuven, Belgium Dyspnea is a prevalent interoceptive sensation and the aversive cardinal symptom in many cardiorespiratory diseases as well as in mental disorders. Especially the unpredictability of the occurrence of dyspnea episodes has been suggested to be highly anxiety provoking for affected patients. Moreover, previous studies demonstrated that unpredictable exteroceptive stimuli increased self-reports and electrophysiological responses of an...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Lindsay T. McDonald1,2*, Marcelo F. Lopez3,4, Kristi L. Helke2,5,6, M.A. McCrackin1,5, James J. Cray Jr.7, Howard C. Becker1,3,4 and Amanda C. LaRue1,2,81Research Services, Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC, United States2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States3Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States4Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, SC, United States5Department of Comparativ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This study indicated that switch from H2 blockers to PPIs reduced delirium and, thus, providing an appropriate strategy to combat drug-induced delirium using antiulcer drugs (Fujii et al., 2012). The ventrolateral preoptic nucleus is a sleep-promoting nucleus located in the basal forebrain. A commonly used intravenous anesthetic, propofol, had been reported to induce sleep and augment the firing rate of neurons in ventrolateral GABAergic preoptic nucleus, but the underlining mechanism is yet to be clearly determined. Interestingly, the propofol-induced inhibition of inhibitory postsynaptic currents on noradrenalin-inhibite...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
How Bad Is Fentanyl? Fentanyl is an extremely dangerous synthetic opioid. Unlike some other opioids that occur naturally, it is man-made for the purpose of helping aid people suffering from extreme pain. It can be administered for recovery after surgery, during cancer treatments or for recovery after a painful injury. The Drug Enforcement Administration (DEA) classifies fentanyl as a Schedule II controlled substance. This means that it is legal for medical use, however, it has an extremely high potential for abuse and addiction. Understanding Fentanyl Significantly stronger than morphine or oxycodone, Fentanyl can be fatal...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Drug Rehab Information Drug Treatment Heroin Painkiller Substance Abuse Synthetic fentanyl prescription drug abuse prescription drug addiction prescription drug detox prescription drug use p Source Type: blogs
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