Head, Neck Melanomas Show Alarming Rise in Young Americans

Researchers found that the incidence of head and neck melanoma rose nearly 4% a year from 1995 to 2001, and 1.2% a year from 2001 to 2014 in children and young adults.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 13 October 2019Source: Seminars in Cancer BiologyAuthor(s): Vikram Shaw, Suyash Srivastava, Sanjay K. SrivastavaAbstractThe recent development of high throughput compound screening has allowed drug repurposing to emerge as an effective avenue for discovering novel treatments for cancer. FDA-approved antipsychotic drugs fluspirilene, penfluridol, and pimozide are clinically used for the treatment of psychotic disorders, primarily schizophrenia. These compounds, belong to diphenylbutylpiperidine class of antipsychotic drugs, are the potent inhibitors of dopamine D2 receptor and calcium chan...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
A scanning electrochemical microscope can detect a cancer biomarker in skin cells collected with sticky tape, no scalpel needed
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Getting a second opinion from a pathologist specially trained in skin lesions -- a dermatopathologist -- yields the most accurate results, the new study found.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Abstract An accurate profiling of the genomic landscape is mandatory to establish the best clinical and therapeutic approach for patients with solid malignancies. Moreover, tumor cells constantly adapt to external pressures-i.e., systemic treatment-with the selection and expansion of resistant subclones and the emergence of heterogeneous overlapping genomic alterations of resistance. The current standard for molecular characterization in cancer is the performance of a tissue tumor biopsy at the time of diagnosis and, when possible, a re-biopsy at the time of progression. However, tissue biopsy is not always feasib...
Source: Cell Research - Category: Cytology Authors: Tags: Recent Results Cancer Res Source Type: research
A skin cancer protection program in Australia led to marked changes in sun-related behaviors that correspond to a reduction in the incidence of melanoma over the same period, suggest survey results.Medscape Medical News
Source: Medscape Med Students Headlines - Category: Universities & Medical Training Tags: Hematology-Oncology News Source Type: news
A new Yale-developed immunotherapy system has been shown to reduce or eliminate melanoma and triple-negative breast and pancreatic tumors in mice.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
With the popularization of Next-generation sequencing technology, targeted cancer therapy based on gene mutations has attracted more and more attention. Aberrant activated mitogen-activated protein kinases (MAPK) pathway is considered to play a crucial role in the occurrence and development of various cancers [1]. Various mutations in pathway components including MEK1/2 can cause the aberrant activation of MAPK signaling pathway [2]. As oncogenic mutations, MEK1 mutations were widely observed in many cancers [1,3,4], while trametinib, a MEK1/2 inhibitor, was limited to treat BRAF-mutant melanoma and non-small-cell lung can...
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Tumour Review Source Type: research
Conclusions: In selected patients, local treatments contribute to controlling oligoprogression for a long time, allowing the continuation of systemic treatment and prolongation of overall survival (OS). Increasing biological and clinical knowledge is improving the accuracy in identifying patients to apply for local ablative therapies.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Communication Source Type: research
Cancers, Vol. 11, Pages 1556: Topical 2′-Hydroxyflavanone for Cutaneous Melanoma Cancers doi: 10.3390/cancers11101556 Authors: Bose Singh Igid Green Singhal Lee Palade Rajan Ball Tonk Hindle Tarbox Awasthi 2′-hydroxyflavanone (2HF) is a dietary flavonoid with anticancer activity towardsmultiple cancers. Here, we report that topically applied 2HF inhibits the growth of intradermalimplants of melanoma in immunocompetent mice. 2HF induced apoptosis and inhibited the growthof the human SK-MEL-24 as well as murine B16-F0 and B16-F10 melanoma cell lines in vitro.Apopto...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Melanoma cells can switch between distinct gene expression profiles, resulting in “proliferative” and “invasive” phenotypes. Signaling pathways involved in this switch were analyzed by gene expression profiling of a cohort of 22 patient-derived melanoma cell lines. E-cadherin/CDH1 negativity was identified as a surrogate marker for the invasive phenotype. CDH1 expression could be turned on and off by modulating activity of p38 or its downstream target MK2, suggesting that this pathway controls melanoma progression.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
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