Clinicopathological features of peripheral ossifying fibroma in a series of 41 patients

Publication date: Available online 8 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): H. Lázare, A. Peteiro, M. Pérez Sayáns, P. Gándara-Vila, J. Caneiro, A. García-García, I. Antón, J.M. Gándara-Rey, J.M. Suárez-PeñarandaAbstractPeripheral ossifying fibromas are benign mesenchymal lesions that usually arise in the anterior maxilla of young female patients. Histologically they consist of spindle cell proliferation with focal mineralisation. We reviewed 48 specimens from 41 patients and recorded the clinical data, sex, and age of the patients, site and size of the lesions, treatment, and postoperative outcome. Histologically the presence of mature, woven bone, cementum, and calcifications were evaluated and evaluated immunohistochemically. Lesions were more frequent in female patients in the third and fourth decade, and were usually in the lower maxilla and smaller than 2 cm. All lesions were conservatively excised, and they relapsed in eight patients. Histopathologically, the lesions were poorly circumscribed, moderately cellular proliferations, with no discernible architectural pattern. All tumours showed some degree of mineralisation, the presence of immature bone being the most common. Immunohistochemical examination showed staining of tumoural cells for smooth muscle actin and CD68. Lesions tended to occur more commonly in female patients, but one decade later than us...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research

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Conclusion: The SRF-RELA gene fusion may represent a subset that in the future may be used to differentiate these myofibromas/myopericytomas from the ACTB-GLI fusion myopericytomas, and PDGFRB may be used to perhaps separate out familial myofibromas from other myofibromas. PMID: 31738635 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
We report on two cases where multifocal disease developed after surgical resection. Chronic inflammation and repetitive trauma may be considered a risk factor for developing multifocal disease. AbstractMultifocal fibromatosis is a rare entity. We report on two cases where multifocal disease developed after surgical resection. Chronic inflammation and repetitive trauma may be considered a risk factor for developing multifocal disease.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
The objective of the present study is to report the case of a 27-years-old female patient, presenting a lesion in the mandible, complaining of an increased volume. Surgical excision was the treatment of choice. The patient is 24 months postoperatively with no signs of relapse.RESUMEN El fibroma osificante perif érico es una lesión benigna, nodular, firme a la palpación, de base sésil o pediculada, de color similar a la mucosa y al epitelio; puede estar intacto o ulcerado. Se observa más en mujeres y acomete solamente la encía. La lesión se asocia a factores irritantes, como ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
Publication date: Available online 8 November 2019Source: Diagnostic and Interventional ImagingAuthor(s): P.-F. Montoriol, B. Bayol
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
We present a rare occurrence of Chondromyxoid fibroma (CMF) in proximal 3rd humerus. 28 year old male with proximal humeral pain had a lesion in the proximal 3rd humerus on X-ray. Since, it appeared as benign lesion and small in size (radiologically looked like intra-osseous ganglion) we decided for excisional biopsy. The histopathological examination revealed that it was Chondromyxoid fibroma.
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
Publication date: Available online 7 November 2019Source: Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyAuthor(s): Pooja Sharma, Mala Kamboj, Anjali NarwalAbstractSpindle cell lesions of head and neck are very diverse entities. These may vary from benignity to malignancy. They exhibit a wide diversity ranging from benign fibroma to malignant peripheral nerve sheath tumor. These can be neural, myofibroblastic, fibroblastic, muscle, vascular, odontogenic, epithelial in origin. Such variable tissues involved provide a diagnostic challenge to the oral pathologists. Among these, neural tumors are very rare i...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
AbstractSoft tissue tumors encompass a wide variety of mesenchymal neoplasms exhibiting diverse clinical, pathologic, and molecular features. Among these, osteoid and/or chondroid matrix deposition in some soft tissue tumors represents a noticeable characteristic. Unlike matrices present in bone tumors where they likely reveal the respective cells of origin (i.e., osteoblastic or chondroblastic precursors), those existing in soft tissue tumors more often denote a metaplastic phenomenon and reflect the diversity of differentiation these tumors can display. While many soft tissue tumor types can occasionally harbor metaplast...
Source: Virchows Archiv - Category: Pathology Source Type: research
ConclusionOne year postoperative with popliteal resection surgery yields a good result. A follow-up is needed for risk of recurrence and malignancy.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
AbstractDesmoid-type fibromatosis is an uncommon disease which mimics sarcoma but is more locally aggressive but with less metastatic potential than sarcoma. Diagnosis is difficult and treatment protocols have changed to include more non-surgical options as compared with sarcoma. This is a retrospective study of the clinical presentation, imaging findings, treatment given, and outcomes of pathologically proven desmoid-type fibromatosis patients who presented to government medical college Kozhikode.
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Authors: Abdulrahman Jnr GO, Das N, Lutchman Singh K Abstract Ovarian cancer is a lethal gynecological malignancy. Although CA-125 is commonly measured in women with adnexal mass, it is estimated that it only has a positive predictive value (PPV) of 69% and a negative predictive value (NPV) of 88% for the detection of ovarian cancer. The aim of this study was to investigate the diagnostic significance and predictive impact of thrombocytosis in women with suspected or confirmed ovarian cancer. This was a retrospective study of women who had surgery for adnexal mass over a 48-month period between September 2014 and S...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
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