Psoriasis After Exposure to Angiotensin-Converting Enzyme Inhibitors: French Pharmacovigilance Data and Review of the Literature

AbstractIntroductionAngiotensin-converting enzyme inhibitors (ACEIs) can induce or aggravate psoriasis. This risk is not specified in the Summary of Product Characteristics (SmPC) of some drugs of this class, such as captopril or enalapril. We aimed to investigate the association between psoriasis and ACEI exposure.MethodsWe analyzed spontaneous reports recorded in the French national Pharmacovigilance Database (FPVD) from 1985 to 31 December 2018. The association between psoriasis and ACEI exposure was assessed using the case/non-case method. We also reviewed literature reports.ResultsOne hundred reports of psoriasis after ACEI exposure were registered in the FPVD. The reporting odds ratio (ROR) was 2.40 (95% CI 1.96 –2.95). Time to onset was 
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research

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To better understand and interpret the trends in cutaneous research, we carried out a network analysis of all the titles of the submitted abstracts of the annual meetings of the European Society of Dermatological Research (ESDR), including the International Investigative Dermatology (IID) meetings between 2010 and 2019. Network analysis is a data science tool to process, analyze, and visualize big sets of data. As expected, psoriasis was the frontrunner in each of the annual meetings, followed by dermatitis and melanoma.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: The ESDR in Numbers Source Type: research
Authors: Michalska A, Teichman R, Kręcisz B, Siudak Z, Stępień R, Sadowski M Abstract Psoriasis is an autoimmune, chronic disease determined by environmental and genetic factors. The occurrence of psoriasis is accompanied by metabolic diseases, cardiovascular diseases (CVD) and depression, disturbances on interpersonal interactions and a tendency towards social isolation. Regardless of the form of psoriasis and the severity of the disease, early arterial lesions are recorded in arterial vessels of patients. Nevertheless, the chance of CVD is higher in the population of patients with severe psoriasis than in pati...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Pathogenesis of psoriasis in the "omic" era. Part II. Genetic, genomic and epigenetic changes in psoriasis. Postepy Dermatol Alergol. 2020 Jun;37(3):283-298 Authors: Nedoszytko B, Szczerkowska-Dobosz A, Stawczyk-Macieja M, Owczarczyk-Saczonek A, Reich A, Bartosiñska J, Batycka-Baran A, Czajkowski R, Dobrucki IT, Dobrucki LW, Górecka-Sokołowska M, Janaszak-Jasiecka A, Kalinowski L, Krasowska D, Purzycka-Bohdan D, Radulska A, Reszka E, Samotij D, Sobalska-Kwapis M, Słominski A, Słominski R, Strapagiel D, Szczêch J, Żmijewski M, Nowicki RJ Abstract Psoriasis is a multifac...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Publication date: Available online 13 August 2020Source: PhytomedicineAuthor(s): Yi Ru, Hongjin Li, Ruoxi Zhang, Ying Luo, Jiankun Song, Le Kuai, Meng Xing, Seokgyeong Hong, Xiaoying Sun, Xiaojie Ding, Yi Lu, Liu Liu, Chen Na, Yaqiong Zhou, Bin Li, Xin Li
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Inflammation is a physiological response to aggression of pathogenic agents aimed at eliminating the aggressor agent and promoting healing. Excessive inflammation, however, may contribute to tissue damage and an alteration of arterial structure and function. Increased arterial stiffness is a well recognized cardiovascular risk factor independent of blood pressure levels and an intermediate endpoint for cardiovascular events. In the present review, we discuss immune-mediated mechanisms by which inflammation can influence arterial physiology and lead to vascular dysfunction such as atherosclerosis and arterial stiffening. We...
Source: Journal of Hypertension - Category: Cardiology Tags: CONSENSUS DOCUMENT Source Type: research
Authors: Peng H, Xian D, Liu J, Pan S, Tang R, Zhong J Abstract Macrophages, a kind of innate immune cells, derive from monocytes in circulation and play a crucial role in the innate and adaptive immunity. Under the stimulation of the signals from local microenvironment, macrophages generally tend to differentiate into two main functional phenotypes depending on their high plasticity and heterogeneity, namely, classically activated macrophage (M1) and alternatively activated macrophage (M2). This phenomenon is often called macrophage polarization. In pathological conditions, chronic persistent inflammation could in...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Publication date: Available online 12 August 2020Source: Microvascular ResearchAuthor(s): Xuping Niu, Qixin Han, Yanmin Liu, Juan Li, Ruixia Hou, Junqin Li, Kaiming Zhang
Source: Microvascular Research - Category: Biochemistry Source Type: research
Publication date: Available online 7 August 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): L.M. Moneva-Leniz, A. Sahuquillo-Torralba, A. Vila-Payeras, A. Mateu-Puchades
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Conclusion Two dietary patterns were identified in a Brazilian sample of psoriasis patients. The prevalence of obesity and metabolic syndrome were greater than in the adult Brazilian population. The fresh diet was associated with lower indicators of metabolic syndrome in this sample.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Abstract We previously reported 2-aminobenzoxazole analogue 1 as a potent ChemR23 inhibitor. The compound showed inhibitory activity against chemerin-induced calcium signaling through ChemR23 internalization in CAL-1 cells, which are cell lines of plasmacytoid dendric cells (pDCs). Furthermore, compound 2 inhibited chemotaxis of CAL-1 triggered by chemerin in vitro. However, we noted a difference in the ChemR23 response to our inhibitor between rodents and non-rodents in a previous study. To address this issue, we performed optimization of ChemR23 inhibitors using CAL-1 cells endogenously expressing human ChemR23 ...
Source: Bioorganic and Medicinal Chemistry - Category: Chemistry Authors: Tags: Bioorg Med Chem Source Type: research
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