A case report of an uncommon presentation of 99mtechnetium pyrophosphate scintigraphy in transthyretin cardiac amyloidosis: A potential diagnostic pitfall, pseudo-positive or pseudo-negative?

In this report, we focus on an inconclusive study case as a potential pitfall of 99mTc-PYP scintigraphy and discuss the interpretation of 99mTc-PYP scintigraphy findings with using both planar and SPECT/CT imaging for improvement of diagnostic accuracy for ATTR cardiac amyloidosis.<Learning objective: The present report describes the importance of distinguishing myocardial uptake from the cardiac blood pool by both planar and single-photon emission computed tomography/computed tomography fusion imaging on 99mtechnetium pyrophosphate (99mTc-PYP) scintigraphy for diagnosis of transthyretin cardiac amyloidosis. To improve diagnostic accuracy, the 99mTc-PYP scintigraphy protocol including the method of evaluation and interpretation of the findings should be unified.>
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research