The polymorphisms (rs3213801 and rs5744533) of DNA polymerase kappa gene are not related with glioma risk and prognosis: A case ‐control study

In this study, we found DNA polymerase kappa variants rs3213801 and rs5744533 are not associated with glioma risk and prognosis, but they are likely to be associated with certain glioma characteristics, such as age and World Health Organization grade. Meanwhile, the age, surgery types, and chemotherapy could be independent prognostic factors in glioma. AbstractDNA polymerase kappa (POLK), one of the specialized Y family DNA polymerases, functions in translesion synthesis and is suggested to be related with cancers. Single nucleotide polymorphisms (SNPs) in specialized DNA polymerases have been demonstrated to be associated with cancer risk. To evaluate the association of two commonPOLK variants (rs3213801 C>T and rs5744533 C>T) with glioma, we conducted a case ‐control study and genotyped these twoPOLK variants in 605 patients and 1300 healthy controls. The association analysis revealed no significant correlations were observed between these twoPOLK SNPs and glioma risk. However, thePOLK rs3213801 CT genotype was found to be higher in older glioma patients ( ≥40) than in younger patients (P = .026). Compared with patients harboring the CC genotype, the frequencies ofPOLK rs5744533 CT and CT+TT genotypes were increased in patients with lower World Health Organization (WHO) grade glioma (P = .028, 0.044, respectively). According to Kaplan‐Meier analysis and log‐rank tests,POLK SNPs were not correlated with either the overall survival or progression ‐free sur...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research