Identification of bifucosylated glycoforms using low ‐energy CID spectra

AbstractWe have used tandem mass spectrometry (MS/MS) ‐based analysis of glycopeptides in order to identify the composition and structure of rare glycoforms. The results illustrate utility of low‐energy MS/MS for structure identification. We have shown the presence of bifucosylated and trifucosylated glycoforms in human α‐1‐acid glycoprotein ( AGP), a major plasma glycoprotein. Fucosylation in the case of AGP always occurs on the antennae; core fucosylation was not observed.

Source: Journal of Mass Spectrometry - October 8, 2019 Category: Chemistry Authors: Andr ás Ács, Lilla Turiák, Ágnes Révész, Károly Vékey, László Drahos Tags: RESEARCH ARTICLE Source Type: research