Safety, Tolerability, and Efficacy of Zilucoplan in Subjects With Generalized Myasthenia Gravis
Condition: Myasthenia Gravis, Generalized Interventions: Drug: zilucoplan (RA101495); Drug: Placebo Sponsor: Ra Pharmaceuticals Recruiting
This study aimed to explore its typical presentation, investigations and treatment through a systematic review of previously reported cases.
Condition: Myasthenia Gravis Interventions: Drug: TAK-079; Drug: TAK-079 Placebo Sponsor: Takeda Not yet recruiting
Condition: Myasthenia Gravis Interventions: Procedure: thymectomy (robotic-assisted thoracoscopic, minimally-invasive thymectomy); Procedure: thymectomy by means of median sternotomy (transsternal); Procedure: no thymectomy (control) Sponsors: Charite University, Berlin, Germany; NeuroCure Clinical Research Center, Charite, Berlin; Department of Surgery, Charite, Berlin; Sana Klinikum Lichtenberg, Berlin Not yet recruiting
Get up-to-date on the latest advancements in the diagnosis and treatment of myasthenia gravis.Current Opinion in Rheumatology
Gangliosides are sialylated glycosphingolipids, highly abundant in our nervous system. Antibodies targeting gangliosides are usually developed as a consequence of molecular mimicry following infections. Antiganglioside antibodies are implicated in many neurological disorders such as acute and chronic polyradiculoneuropathies which includes different variants of Guillain-Barr é syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy. Presence of such antibodies in paraneoplastic peripheral neuropathy, neurodegenerative disorders, multiple sclerosis, myasthenia gravis and am...
ConclusionSurgical removal of thymoma cured myasthenia gravis in our case. We focused on proper preoperative optimization of myasthenia gravis symptoms before thymectomy.
Immune-checkpoint inhibitors (ICIs) are novel therapeutic agents that have demonstrated relevant anti-tumor responses in multiple cancer types. They produce a potentiation of the immune response against the cancer by blocking the negative down-regulation of T cells. Checkpoint inhibitor-associated neurological side effects are rare but also potentially life-threatening .
The thymus plays an essential role in the pathogenesis of myasthenia gravis (MG). In patients with MG, natural regulatory T cells (nTreg), a subpopulation of T cells that maintain tolerance to self-antigens, a...
Publication date: November 2019Source: Journal of Clinical Neuroscience, Volume 69Author(s): Gao-Mei Cai, Zhe Gao, Yao-Xian Yue, Yan-Chen Xie, Xiang Gao, Hong-Jun Hao, Xian-Jun Zhang, Qi Wang, Bing Liang, Hai-Feng LiAbstractAbnormal CTLA-4 expression is involved in the development of myasthenia gravis (MG), and serum CTLA-4 levels are positively correlated with serum anti-AChR antibody concentration, which might be related with the severity of MG. Polymorphism in CTLA-4 gene is associated with various autoimmune disorders. We investigated the association of polymorphism in CTLA-4 gene with the clinical variables and severi...