Novartis blockbuster eye med wins FDA approval

Beovu injections treat wet age-related macular degeneration that affects 20 million people worldwide, according to the company
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news

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Condition:   Neovascular Age-related Macular Degeneration Intervention:   Drug: Brolucizumab 6 mg solution for intravitreal injection Sponsors:   Vista Klinik;   Novartis Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: From the Brazilian SUS perspective, bevacizumab is more cost-effective than ranibizumab for the treatment of neovascular age-related macular degeneration. Its use could allow potential annual savings in health budget.RESUMO Objetivo: Estudar o custo-efetividade do ranibizumabe e bevacizumabe no tratamento da degenera ção macular relacionada à idade neovascular. Métodos: Utilizamos um modelo de árvore de decisão para analisar a relação custo-efetividade do ranibizumabe e bevacizumabe no tratamento da degeneração macular relacionada à i...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research
Conclusions: There is extensive and increasing evidence that a range of retinal vascular signs and disease are closely linked to CeVD, including subclinical and clinical CeVD. New technology including AI-DL will allow further translation to clinical utilization.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Disease of the Year: Cerebrovascular Disorders Source Type: research
To describe the spectral-domain optical coherence tomography (SD-OCT) features of fibrotic lesions associated with neovascular age-related macular degeneration (nAMD) and to outline the progression pathways from initial macular neovascular lesions (CNV) to fibrosis.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Contributors : Hui Cai ; Jie Gong ; Lucian Del Priore ; Mark A FieldsSeries Type : Expression profiling by arrayOrganism : Homo sapiensComparing iPS derived RPE cells from human AMD and non-AMD donorsIt has been a challenge to model retinal disorders such as geographic atrophy (GA) in in vivo animals, primarily because several factors, including genetics and aging itself, contribute to disease phenotype of age-related macular degeneration (AMD). We generated retinal pigment epithelial (RPE) cells from patients with advanced AMD and assessed their ability to model disease. We observed alterations in the transcriptome of AMD...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Deposition of hydroxyapatite (HAP) basal to the retinal pigment epithelium (RPE) is linked to the progression of age-related macular degeneration (AMD). Serum-deprivation of RPE cells in culture mimics some features of AMD. We now show that serum-deprivation also leads to the induction of amelotin (AMTN), a protein involved in hydroxyapatite mineralization in enamel. HAP is formed in our culture model and is blocked by siRNA inhibition of AMTN expression. In situ hybridization and immunofluorescence imaging of human eye tissue show that AMTN is expressed in RPE of donor eyes with geographic atrophy ( “dry” AMD)...
Source: Translational Research - Category: Research Authors: Source Type: research
AbstractPurposeTo determine the changes in the cone-driven functions in patients with age-related macular degeneration (AMD) treated with intravitreal aflibercept.MethodsWe studied 44 eyes of 44 patients diagnosed with AMD whose mean age was 75  years. The contralateral unaffected eyes served as controls. All patients were initially treated with 3 consecutive monthly intravitreal aflibercept injections and thereafter with bimonthly injections for 12 months. Full-field cone electroretinograms (cone ERGs) were recorded at the baseline and at 3, 6, and 12 months after beginning the intravitreal aflibercept inje...
Source: Documenta Ophthalmologica - Category: Opthalmology Source Type: research
12th Sayer Vision Research Lecture Dr. Bharti's laboratory developed and functionally validated in vitro models of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelial cells (RPE). The RPE cells, matured on a biodegradable scaffold, formed a functional monolayer patch. The FDA recently approved a phase I/IIa safety and feasibility clinical trial to test an autologous iPSC-RPE patch in patients with the geographic atrophy form of age-related macular degeneration.Air date: 4/21/2020 11:00:00 AM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Authors: Merrigan SL, Park B, Ali Z, Jensen LD, Corson TW, Kennedy BN Abstract Aberrant ocular angiogenesis can underpin vision loss in leading causes of blindness, including neovascular age-related macular degeneration and proliferative diabetic retinopathy. Current pharmacological interventions require repeated invasive administrations, may lack efficacy and are associated with poor patient compliance and tachyphylaxis. Vitamin D has de novo anti-angiogenic properties. Here, our aim was to validate the ocular anti-angiogenic activity of biologically active vitamin D, calcitriol, and selected vitamin D analogue, 2...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusion: Impairment of the CC, assessed by flow-deficit percentages, was most prominent closest to CNV boundaries. The lesion-centered zonal analysis technique enabled quantitative CC measurements relative to focal lesions. Understanding how processing steps, imaging/processing parameters, and artifacts can affect quantitative CC measurements is important for longitudinal, OCTA-based studies of disease progression, and treatment response.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
More News: Age-Related Macular Degeneration (AMD) | Pharmaceuticals