Cronos Titin is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function.

Conclusions: We demonstrate that Cronos titin is expressed in developing human cardiomyocytes and is able to support partial sarcomere formation in the absence of full-length titin. Further, Cronos titin is necessary for proper sarcomere function in hiPSC-CMs. Additional investigation is necessary to understand the molecular mechanisms of this novel isoform and how it contributes to human cardiac disease.
PMID: 31587567 [PubMed - as supplied by publisher]

Source: Circulation - October 6, 2019 Category: Cardiology Authors: Zaunbrecher RJ, Abel AN, Beussman K, Leonard A, von Frieling-Salewsky M, Fields PA, Pabon L, Reinecke H, Yang X, Macadangdang J, Kim DH, Linke WA, Sniadecki NJ, Regnier M, Murry CE Tags: Circulation Source Type: research