Reversion Failure of Neuromuscular Block in Myasthenia Gravis Reversion Failure of Neuromuscular Block in Myasthenia Gravis

This case report highlights the importance of cholinesterase inhibitors management and neuromuscular block monitoring in the perioperative period for patients with myasthenia gravis.BMC Anesthesiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

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Abstract This case report describes an exacerbation of ocular myasthenia gravis after intravitreal injection using local anesthesia. A possible association with local therapeutic agents is critically discussed but cannot be excluded. PMID: 31555837 [PubMed - as supplied by publisher]
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
Using a minimum dose of neuromuscular blockade (NMB) to achieve intubation condition is one of the goals in anaesthesia management of patients with myasthenia gravis (MG) for thoracoscopic (VATS) thymectomy. H...
Source: BMC Anesthesiology - Category: Anesthesiology Authors: Tags: Research article Source Type: research
Abstract Patients diagnosed with ocular myasthenia gravis (MG) and mitral valve disease represent a significant perioperative management problem, especially for the anaesthesiologist, due to complex inter-actions between the disease, drugs to treat the disease, and anaesthetic agents, such as neuromuscu-lar blocking agents (NMBAs). This paper describes the successful management of a 31-year-old female with mitral valve stenosis and ocular MG who was diagnosed with MG 4 years prior to the indication for cardiac surgery. Preoperatively, the patient was under treatment with Pyridostigmine and Prednisone. Mitral valve...
Source: The Heart Surgery Forum - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Heart Surg Forum Source Type: research
This report shows that the use of rocuronium-sugammadex is not free from flaws and highlights the importance of cholinesterase inhibitors manage...
Source: BMC Anesthesiology - Category: Anesthesiology Authors: Tags: Case report Source Type: research
This study was carried out in accordance with the recommendations of “NIH Guide for Care and Use of Laboratory Animal protocols” and of the Institutional Animal Care and Use Committee of Shiga University of Medical Science (SUMS). The protocol was approved by SUMS. Six adult male Balb/c mice (5-weeks-old) were purchased from Clea Japan Inc. (Konan, Japan). Each mouse (labeled H1-H6) received subcutaneous injections of 0.1 ml of TiterMax Gold adjuvant (Sigma-Aldrich, Saint-Louis, MO, USA) containing 5 mg/ml KLH-conjugated peptide into multiple sites of the neck and back skin with at a 2-week interval. Antisera, ...
Source: Frontiers in Neuroanatomy - Category: Neurology Source Type: research
In the early 1900s, chance observations of improved symptoms in several myasthenic patients undergoing thyroidectomy for goiters with concomitant resection of the adjacent thymus gland, first suggested a possible association between the thymus and myasthenia gravis. With the remarkable progress made in the understanding and treatment of myasthenia and in the anesthetic, surgical, and postoperative management of patients undergoing thoracic procedures, the initial high morbidity and mortality associated with thymectomy have been all but eliminated, and thymectomy is frequently incorporated into the long-term management stra...
Source: Thoracic Surgery Clinics - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Ramandeep Bansal, Manoj Kumar Goyal, Manish ModiIndian Journal of Pharmacology 2018 50(6):302-308 The management of myasthenia gravis (MG) during pregnancy requires special skills as both diseases as well as its treatment can have deleterious effects on mother and fetus. MG often affects women in second and third decades of life during the childbearing age. Exacerbations of MG are likely to occur during the first trimester and postpartum period. The treatment of MG during pregnancy needs to be individualized depending on the severity of MG as well as the efficacy of various treatment modalities and their possible harmful ...
Source: Indian Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
Many people with bipolar disorder struggle with self-loathing. Maybe the self-loathing starts as the depressive phase does with all sorts of awful thoughts about yourself. Because that’s how depression works: It outright lies, and inflicts pain. You can’t do anything right. You’re an abject failure. You’re also stupid. And worthless, and no one will ever really love you for you. You are not attractive or thin or strong enough. You are weak, and you are an embarrassment. Maybe it happens after a manic or hypomanic episode, because you feel terrible about what you did or said during th...
Source: Psych Central - Category: Psychiatry Authors: Tags: Bipolar Disorders General Self-Esteem Self-Help Autoimmune Disease Bipolar Disorder Mood Disorder Negative Thoughts Self Hatred Self Loathing Source Type: news
ConclusionsEven if accurate component orientation is attained in total hip arthroplasty, patients with neuromuscular disorders such as myasthenia gravis have a potential risk of muscle weakness in the affected limb. Therefore, physicians ’ instructions and patients’ careful attention are required to prevent dislocation due to excessive hip joint laxity under conditions of motor weakness.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Authors: Cichos KH, Lehtonen EJ, McGwin G, Ponce BA, Ghanem ES Abstract INTRODUCTION: Orthopaedic surgeons are wary of patients with neuromuscular (NM) diseases as a result of perceived poor outcomes and lack of data regarding complication risks. We determined the prevalence of patients with NM disease undergoing total joint arthroplasty (TJA) and characterized its relationship with in-hospital complications, prolonged length of stay, and total charges. METHODS: Data from the Nationwide Inpatient Sample from 2005 to 2014 was used for this retrospective cohort study to identify 8,028,435 discharges with total jo...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
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