Incidence and Risk Factors for IBS in Population-based Studies Incidence and Risk Factors for IBS in Population-based Studies

This study aimed to identify the incidence and risk factors for developing new onset irritable bowel syndrome in population-based cohorts who did not have prior gastrointestinal infection.Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

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Publication date: Available online 18 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): I.A.M. van Thiel, S. Botschuijver, W.J. de Jonge, J. SeppenAbstractVisceral pain, characterized by abdominal discomfort, originates from organs in the abdominal cavity and is a characteristic symptom in patients suffering from irritable bowel syndrome, vulvodynia or interstitial cystitis. Most organs in which visceral pain originates are in contact with the external milieu and continuously exposed to microbes. In order to maintain homeostasis and prevent infections, the immune- and nervous sy...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Authors: Lee JY, Kim N, Park JH, Nam RH, Lee SM, Song CH, Kim G, Na HY, Choi YJ, Kim JJ, Lee DH Abstract Background/Aims: Emerging evidence shows that the mechanism of irritable bowel syndrome (IBS) is associated with neurotrophic factors and tight junction proteins (TJPs) It is known that there are sex differences in the pathophysiology of IBS. The aim of the present study is to determine expression levels of neurotrophic factors, TJPs, and cytokines according to IBS subtype and sex. Methods: From 59 IBS (33 IBS-constipation, 21 IBS-diarrhea, and 5 IBS-mixed) and 36 control patients, colonic mucosa mRNA expres...
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research
New research discovers that receptors in the nervous system that cause itchy skin also reside in the gut, explaining chronic IBS pain.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Irritable Bowel Syndrome Source Type: news
This article provides an overview of the current knowledge on the pharmacological mechanisms of trimebutine and its clinical applications in gastrointestinal disorders. Its biochemical properties and the complex mechanisms of action, along with a well-studied pharmacological safety, make this compound still actual and valuable. PMID: 31617696 [PubMed - in process]
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Conclusion: The finding of this study puts a global perspective on metabolomics and microbiota profiling in IBS patients and provides a theoretical basis for future research on pathophysiology of IBS.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Condition:   Irritable Bowel Syndrome With Diarrhea Interventions:   Drug: ORP-101;   Drug: Placebo Sponsors:   OrphoMed, Inc.;   PPD Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Genetic factors increase the risk of irritable bowel syndrome (IBS). Analysis of single nucleotide polymorphisms (SNPs) has been used in IBS patients, but the findings are inconsistent. The goal of this review...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
ConclusionsApproximately 45% of patients with unexplained gas and bloating had SIBO, fructose, or lactose intolerance; another 9 –16% had visceral hypersensitivity. Pretest symptoms were poor predictors, but symptoms during the breath tests were useful. Breath tests are safe, provide significant diagnostic yield, and could be useful in routine gastroenterology practice.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Contributors : Savanne Holster ; Guido J Hooiveld ; Robert J Brummer ; Julia K önigSeries Type : Expression profiling by arrayOrganism : Homo sapiensIn this randomised placebo-controlled trial, irritable bowel syndrome (IBS) patients were treated with faecal material from a healthy donor (n=8, allogenic FMT) or with their own faecal microbiota (n=8, autologous FMT). The faecal transplant was administered by whole colonoscopy into the caecum (30 g of stool in 150 ml sterile saline). Two weeks before the FMT (baseline) as well as two and eight weeks after the FMT, the participants underwent a sigmoidoscopy, and biopsies...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Auricular neurostimulation therapy, in which a non-invasive device delivers percutaneous electrical nerve field stimulation (PENFS) to the external ear, is effective in pediatric patients with functional abdominal pain disorders. Preclinical studies showed that PENFS modulates central pain pathways and attenuates visceral hyperalgesia. We evaluated the efficacy of PENFS in adolescents with irritable bowel syndrome (IBS).
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
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