Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect.

CONCLUSIONS: These findings suggest that BD is associated with minimal changes in whole blood gene expression independent of medication use but emphasize the importance of accounting for medication use and cell type heterogeneity in psychiatric transcriptomic studies. The results of this study add to mounting evidence of lithium's cell signaling and immune-related mechanisms.
PMID: 31589133 [PubMed - as supplied by publisher]

Source: Psychological Medicine - October 6, 2019 Category: Psychiatry Authors: Krebs CE, Ori APS, Vreeker A, Wu T, Cantor RM, Boks MPM, Kahn RS, Olde Loohuis LM, Ophoff RA Tags: Psychol Med Source Type: research