Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect.

Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect. Psychol Med. 2019 Oct 07;:1-12 Authors: Krebs CE, Ori APS, Vreeker A, Wu T, Cantor RM, Boks MPM, Kahn RS, Olde Loohuis LM, Ophoff RA Abstract BACKGROUND: Bipolar disorder (BD) is a highly heritable mood disorder with complex genetic architecture and poorly understood etiology. Previous transcriptomic BD studies have had inconsistent findings due to issues such as small sample sizes and difficulty in adequately accounting for confounders like medication use. METHODS: We performed a differential expression analysis in a well-characterized BD case-control sample (Nsubjects = 480) by RNA sequencing of whole blood. We further performed co-expression network analysis, functional enrichment, and cell type decomposition, and integrated differentially expressed genes with genetic risk. RESULTS: While we observed widespread differential gene expression patterns between affected and unaffected individuals, these effects were largely linked to lithium treatment at the time of blood draw (FDR
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research

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This week’s Psychology Around the Net explores positive morning affirmations to tell your reflection (yep!), offers tips for surviving holiday family gatherings, what hiding Instagram likes could mean for your mental health, and more. The 6 Best Things to Say to Yourself in the Mirror According to Mental Health Pros: Think of these morning affirmations as an act of self-care. It might feel awkward at first, but starting the day in front of your mirror, taking a deep breath, and saying to the reflection “I’m so proud of you” (or “I’m a f****** bad***!”) can boost your self-esteem, ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net Affirmations employees Family Holidays instagram managers Motivation Self Care Self-Esteem workplace Source Type: blogs
Authors: Muneer A Abstract Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric conditions like major depressive disorder, bipolar disorder, and schizophrenia may be associated with accelerated cellular aging, indicated by shortened leukocyte telomere length (LTL), which could underlie this connection. Telomere shortening occurs with repeated cell division and is reflective of a cell's mitotic history. It is also influenced by cumulative...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Aydin O, Unal Aydin P, Arslan A Abstract This chapter presents an overview of accumulating neuroimaging data with emphasis on translational potential. The subject will be described in the context of three disease states, i.e., schizophrenia, bipolar disorder, and major depressive disorder, and for three clinical goals, i.e., disease risk assessment, subtyping, and treatment decision. PMID: 31705495 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Mendelian randomisation technique suggests cause-and-effect relationship exists between smoking and depression and schizophrenia Related items fromOnMedica Child mental health linked to families who struggle Bipolar disorder is frequently misdiagnosed as depression Family, friends and work key to mental wellbeing Forcible admissions to psychiatric care have soared Mental health patients being sent long distances for treatment
Source: OnMedica Latest News - Category: UK Health Source Type: news
Publication date: Available online 30 October 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Tian Tian, Yongtao Yang, Bing Xu, Yinhua Qin, Guangchao Zang, Chanjuan Zhou, Peng Zheng, Jin Chen, Ke Cheng, Jianjun Chen, Xue Gong, Peng XieAbstractPigment epithelium-derived factor (PEDF, also known as SERPINF1) is a secreted glycoprotein with neuroprotective effects. However, the potential role of PEDF in major depressive disorder (MDD) remains largely unknown. Here, applying two-dimensional gel electrophoresis (2-DE) proteomics, we found that PEDF levels were significantly decreased in the ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Authors: Ayyagari R, Thomason D, Mu F, Philbin M, Carroll B Abstract Aims: To evaluate the association of relapse and healthcare resource utilization in patients with schizophrenia (SZ), bipolar disorder (BD), or major depressive disorder (MDD) who switched antipsychotic medication versus those who did not.Materials and Methods: Medicaid claims from six US states spanning 6 years were retrospectively analyzed for antipsychotic switching versus non-switching. For all patients with SZ, BD, or MDD, and for the subset of patients who also had ≥1 extrapyramidal symptoms (EPS) diagnosis at baseline, times to the follo...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antidepressant Antipsychotic General Medications Mental Health and Wellness Not Crazy Podcast Psychology Research Sexuality Stimulants Treatment Source Type: blogs
Abstract Epidemiological studies demonstrate an association between asthma and mental health disorders, although little is known about the shared genetics and causality of this association. Thus, we aim to investigate shared genetic and the causal link between asthma and mental health disorders.We conducted a large-scale genome-wide cross-trait association study to investigate genetic overlap between asthma from UK Biobank and 8 mental health disorders from Psychiatric Genomics Consortium, including: attention deficit hyperactivity disorder (ADHD), anxiety disorder (ANX), autism spectrum disorder, bipolar disorder...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Eur Respir J Source Type: research
The word “schizophrenia” tends to conjure ideas of dramatic imagery: hallucinations, delusions, insane asylums in the general public’s mind. Most people don’t think of the boring parts that consume many with schizophrenia, like lacking the motivation to get out of bed, to make friends… Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard discuss avolition and ways to help motivate loved ones in this episode of Inside Schizophrenia. Family Counselor Ms. Breen joins to share ways to sort through dilemmas. And Rachel does an experiment on her own to address her lack of mo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior General Inside Schizophrenia Mental Health and Wellness Motivation and Inspiration Psychology avolition Lack Of Motivation Living With Schizophrenia Source Type: blogs
CONCLUSIONS: For most mental disorders, refugees were less likely to be admitted to hospital for suicide attempt or die by suicide compared with Swedish-born individuals. Further research on risk and protective factors for suicide attempt and suicide among refugees with mental disorders is warranted. DECLARATION OF INTEREST: None. PMID: 31608856 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
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