Variation near MTNR1A associates with early development and interacts with seasons.

Variation near MTNR1A associates with early development and interacts with seasons. J Sleep Res. 2019 Oct 07;:e12925 Authors: Sulkava S, Taka AM, Kantojärvi K, Pölkki P, Morales-Muñoz I, Milani L, Porkka-Heiskanen T, Saarenpää-Heikkilä O, Kylliäinen A, Juulia Paavonen E, Paunio T Abstract Melatonin is a circadian regulatory hormone with neuroprotective properties. We have previously demonstrated the association of the genetic variant rs12506228 near the melatonin receptor 1A gene (MTNR1A) with intolerance to shift-work. Furthermore, this variant has been connected to Alzheimer's disease. Because of the previously suggested role of melatonin signalling in foetal neurocognitive and sleep development, we studied here the association of rs12506228 with early development. The study sample comprised 8-month-old infants from the Finnish CHILD-SLEEP birth cohort (n = 1,301). Parental questionnaires assessed socioemotional, communication and motor development, as well as sleep length and night awakenings. The A allele of rs12506228 showed an association with slower socioemotional (p = .025) and communication (p = .0098) development, but no direct association with sleep. However, the association of the Finnish seasons with infant sleep length interacted with rs12506228. Taken together, rs12506228 near MTNR1A, which has been previously linked to adult and elderly traits, is shown here to associate with slower early cognitive devel...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research