Variation near MTNR1A associates with early development and interacts with seasons.

Variation near MTNR1A associates with early development and interacts with seasons. J Sleep Res. 2019 Oct 07;:e12925 Authors: Sulkava S, Taka AM, Kantojärvi K, Pölkki P, Morales-Muñoz I, Milani L, Porkka-Heiskanen T, Saarenpää-Heikkilä O, Kylliäinen A, Juulia Paavonen E, Paunio T Abstract Melatonin is a circadian regulatory hormone with neuroprotective properties. We have previously demonstrated the association of the genetic variant rs12506228 near the melatonin receptor 1A gene (MTNR1A) with intolerance to shift-work. Furthermore, this variant has been connected to Alzheimer's disease. Because of the previously suggested role of melatonin signalling in foetal neurocognitive and sleep development, we studied here the association of rs12506228 with early development. The study sample comprised 8-month-old infants from the Finnish CHILD-SLEEP birth cohort (n = 1,301). Parental questionnaires assessed socioemotional, communication and motor development, as well as sleep length and night awakenings. The A allele of rs12506228 showed an association with slower socioemotional (p = .025) and communication (p = .0098) development, but no direct association with sleep. However, the association of the Finnish seasons with infant sleep length interacted with rs12506228. Taken together, rs12506228 near MTNR1A, which has been previously linked to adult and elderly traits, is shown here to associ...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research

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CONCLUSION: We found no evidence that long-term exposure to work-related sleep loss had resulted in cognitive decline or early dementia symptoms in this sample of retired maritime pilots. PMID: 31726459 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Epileptic activity without visible convulsions is common in Alzheimer's disease (AD) and may contribute adversely to the disease progress and symptoms. Transgenic mice with amyloid plaque pathology also display epileptic seizures, but those are too infrequent to assess the effect of anti-epileptic treatments. Besides spontaneous seizures, these mice also display frequent epileptic spiking in epidural EEG recordings, and these have provided a means to test potential drug treatment to AD-related epilepsy. However, the origin of EEG spikes in transgenic AD model mice has remained elusive, which makes it difficult to relate el...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
Conclusions: The iterative refinement process was successful in finalizing the intervention program, with evidence of sleep improvements. Formal pilot testing of the program will provide further information on feasibility and effectiveness. IMPLICATIONS FOR REHABILITATION Our dyadic behavioral sleep program can be tailored to various types of sleep problems among patients with Alzheimer's disease and their family caregivers, with the goal of improving daytime function by reducing sleep disturbances at night. Caregiver training and participation of both members of the dyad in sleep management may benefit the patients' sleep...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
The Spanish Ministry of Science, Innovation and Universities has published the call for PhD Students 2019. The application period is from 17/10/19 to 07/11/19 at 14:00h.The call offers:1 PHD STUDENT POSITION (4-YEAR CONTRACT)  TO JOIN PROJECT PGC2018-093408-B-I0- THALANG – FUNCTIONAL AND STRUCTURAL CONTRIBUTIONS OF THE HUMAN THALAMUS TO LANGUAGE SYSTEMS ACROSS DEVELOPMENT TO BE SUPERVISED BY PEDRO M. PAZ-ALONSOKey words: Thalamus, Language Systems, Reading, Vision, Functional Connectivity, Structural Connectivity, Lateral Geniculate Nucleus, Medial Geniculate Nucleus, PulvinarSummar...
Source: Talking Brains - Category: Neuroscience Authors: Source Type: blogs
Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by the hypothalamus. The main biological actions of orexins, focused on the central nervous system, are to control the sleep/wake process, appetite and feeding, energy homeostasis, drug addiction, and cognitive processes. These effects are mediated by two G protein-coupled receptor (GPCR) subtypes named OX1R and OX2R. In accordance with the synergic and dynamic relationship between the nervous and immune systems, orexins also have neuroprotective and immuno-regulatory (i.e., anti-inflammatory) properties. The present review gathers recen...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
MONDAY, Oct. 21, 2019 -- Long sleep duration predicts seven-year cognitive decline among U.S. Hispanic/Latino patients, according to a study published online Oct. 9 in Alzheimer's&Dementia. Alberto R. Ramos, M.D., from the University of Miami...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Authors: Ramos AR, Tarraf W, Wu B, Redline S, Cai J, Daviglus ML, Gallo L, Mossavar-Rahmani Y, Perreira KM, Zee P, Zeng D, Gonzalez HM Abstract INTRODUCTION: To determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247). METHODS: The exposures were baseline SDB, daytime sleepiness, insomnia, and sleep duration. The outcomes were change in episodic learning and memory (B-SEVLT-Sum and SEVLT-Recall), language (word fluency [WF]), processing speed (Digit Symbol Substitution), and a cognitive ...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
I’ve been interested in this topic ever since, months ago, I watched an interview on CNN with the neuroscientist Matthew Walker. Eight hours of sleep, he says, is what we need. Eight hours of sleep in complete darkness (otherwise our brains won’t release melatonin, something I didn’t know…). An important point (again, something I didn’t know!): taking naps to catch up on our sleep doesn’t count. “Unfortunately, says Matthew Walker,” “sleep is not like the bank. You cannot accumulate a debt and then hope to pay it off at a later time.” And, he added, “Human...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll sleep deprivation Source Type: blogs
Publication date: Available online 9 October 2019Source: Alzheimer's &DementiaAuthor(s): Alberto R. Ramos, Wassim Tarraf, Benson Wu, Susan Redline, Jianwen Cai, Martha L. Daviglus, Linda Gallo, Yasmin Mossavar-Rahmani, Krista M. Perreira, Phyllis Zee, Donglin Zeng, Hector M. GonzalezAbstractIntroductionTo determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247).MethodsThe exposures were baseline SDB, daytime sleepiness, insomnia, and sleep duration. The outcomes were change in episodic learning ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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