The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle [Neuroscience]

Astrocytes express the 3-phosphoglycerate dehydrogenase (Phgdh) enzyme required for the synthesis of l-serine from glucose. Astrocytic l-serine was proposed to regulate NMDAR activity by shuttling to neurons to sustain d-serine production, but this hypothesis remains untested. We now report that inhibition of astrocytic Phgdh suppressed the de novo synthesis of...

Source: Proceedings of the National Academy of Sciences - October 7, 2019 Category: Science Authors: Samah Neame, Hazem Safory, Inna Radzishevsky, Ayelet Touitou, Francesco Marchesani, Marialaura Marchetti, Shai Kellner, Shai Berlin, Veronika N. Foltyn, Simone Engelender, Jean-Marie Billard, Herman Wolosker Tags: Biological Sciences Source Type: research