Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus [Microbiology]

Cedar virus (CedV) is a bat-borne henipavirus related to Nipah virus (NiV) and Hendra virus (HeV), zoonotic agents of fatal human disease. CedV receptor-binding protein (G) shares only ∼30% sequence identity with those of NiV and HeV, although they can all use ephrin-B2 as an entry receptor. We demonstrate that...

Source: Proceedings of the National Academy of Sciences - October 7, 2019 Category: Science Authors: Eric D. Laing, Chanakha K. Navaratnarajah, Sofia Cheliout Da Silva, Stephanie R. Petzing, Yan Xu, Spencer L. Sterling, Glenn A. Marsh, Lin-Fa Wang, Moushimi Amaya, Dimitar B. Nikolov, Roberto Cattaneo, Christopher C. Broder, Kai Xu Tags: Biological Sciences Source Type: research