Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence [Biophysics and Computational Biology]

A new evaluation of previously published data suggested to us that the accumulation of mutations might slow, rather than increase, as individuals age. To explain this unexpected finding, we hypothesized that normal stem cell division rates might decrease as we age. To test this hypothesis, we evaluated cell division rates...

Source: Proceedings of the National Academy of Sciences - October 7, 2019 Category: Science Authors: Cristian Tomasetti, Justin Poling, Nicholas J. Roberts, Nyall R. London Jr., Meredith E. Pittman, Michael C. Haffner, Anthony Rizzo, Alex Baras, Baktiar Karim, Antonio Kim, Christopher M. Heaphy, Alan K. Meeker, Ralph H. Hruban, Christine A. Iacobuzio-Don Tags: Biological Sciences Source Type: research