Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer [Medical Sciences]

The presence of progenitor or stem cells in the adult pancreas and their potential involvement in homeostasis and cancer development remain unresolved issues. Here, we show that mouse centroacinar cells can be identified and isolated by virtue of the mitochondrial enzyme Aldh1b1 that they uniquely express. These cells are necessary...

Source: Proceedings of the National Academy of Sciences - October 7, 2019 Category: Science Authors: Ekaterina Mameishvili, Ioannis Serafimidis, Sara Iwaszkiewicz, Mathias Lesche, Susanne Reinhardt, Nora Bolicke, Maren Buttner, Dimitris Stellas, Adriana Papadimitropoulou, Matthias Szabolcs, Konstantinos Anastassiadis, Andreas Dahl, Fabian Theis, Argiris Tags: PNAS Plus Source Type: research