Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis [Immunology and Inflammation]

cis-Aconitate decarboxylase (CAD, also known as ACOD1 or Irg1) converts cis-aconitate to itaconate and plays central roles in linking innate immunity with metabolism and in the biotechnological production of itaconic acid by Aspergillus terreus. We have elucidated the crystal structures of human and murine CADs and compared their enzymological properties...

Source: Proceedings of the National Academy of Sciences - October 7, 2019 Category: Science Authors: Fangfang Chen, Peer Lukat, Azeem Ahmed Iqbal, Kyrill Saile, Volkhard Kaever, Joop van den Heuvel, Wulf Blankenfeldt, Konrad Bussow, Frank Pessler Tags: PNAS Plus Source Type: research