Caroline Wyatt: The fight to reverse damage caused by MS

The BBC's Caroline Wyatt looks at what medical advances might bring for people with multiple sclerosis.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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This study evaluated whether the expression and cellular localization of periostin changes in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis. Western blot analysis revealed that periostin was significantly upregulated in the spinal cord of EAE-induced mice in the effector stage, and did not significantly decrease in the recovery stage of EAE, compared with normal control. Periostin was constitutively detected in the neurons, ependymal cells, vascular endothelial cells, and astrocytes of normal mice. In the paralytic stage of EAE, periostin immunorea...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
(Natural News) Multiple sclerosis is scary enough on its own, especially since it is expensive and painful to treat. But a new study warns that one out of every five patients diagnosed with the disease has a different medical condition that shares the same symptoms. A common cause of disability, multiple sclerosis takes place when...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
The objective of this study was to validate the use of the BoT in MS, by assessing its ability to distinguish between MS patients and matched controls, as well as detect CI among MS patients, by analysing its correlation with standard cognitive tests and its reliability and learning effects in repeatable use.MethodsThe BoT was applied in 30 patients with MS consecutively selected and 30 age- and education-matched controls, first in a hospital clinic, under supervision, and then 1  week later from home. After these first two trials, MS patients repeated the test from home every 4 weeks for 3 months. A standar...
Source: Neurological Sciences - Category: Neurology Source Type: research
Publication date: Available online 19 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Hiroki Hoshino, Yoko Shirai, Hiroe Konishi, Takashi Yamamura, Norikazu ShimizuAbstractFulminant demyelinating disease including acute disseminating encephalitis, multiple sclerosis (MS) variants, and neuromyelitis optica spectrum disorder (NMOSD) are often managed with similar acute treatment such as intravenous methylprednisolone and plasma exchange. On the other hand, long-term management varies. The choice of the drug is based on several factors including the activity and severity of the disease course. Tocilizum...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 19 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Eslam Shosha, Abdulla Al Asmi, Eman Nasim, Jihad Inshasi, Fatima Abdulla, Yaser Al Malik, Ahmed Althobaiti, Mohamed Alzawahmah, Hind A Alnajashi, Mohamed Binfalah, Awad AlHarbi, Ibtisam A. Thubaiti, Samar F Ahmed, Jasem Al-Hashel, Mortada Elyas, Ramachandiran Nandhagopal, Arunodaya Gujjar, Talal Al Harbi, Ghadah Al Towaijri, Isa A AlsharooqiAbstractObjectiveTo describe the clinical and radiological characteristics of neuromyelitis optica spectrum disorders (NMOSD) patients from the Arabian Gulf relative to anti-aqua...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionMS patients with a higher disability at TN onset and with a longer interval between MS and TN onset had differing clinical features and outcomes: pain was more frequently bilateral, surgery was more frequent and anticipated, and preventive medication discontinuation due to pain remission was less common.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We report the case of a 9-year-old girl with linear scleroderma en coup de sabre (LSCS) who developed progressive white matter involvement, presenting as intractable hemiplegic migraine-like attacks induced by exercise. After a period of severely aggressive course, clinical and radiological stabilization was achieved under immunosuppressant treatment. Intrathecal synthesis of IgG and lymphocytic pleocytosis provided indirect evidence of a chronic inflammatory process of the central nervous system. We discuss the possible immunopathogenic mechanisms responsible for the neurocutaneous involvement in LSCS, favouring the hypot...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Luis Andreu, Domingo J. Ramos-Campo, Vicente Ávila-Gandía, Tomas Freitas, Linda H. Chung, Jacobo Á. Rubio-AriasAbstractBackgroundWhole-body vibration training (WBVT) has been used in people with relapsing-remitting multiple sclerosis (pwMS), showing improvements in different neuromuscular and mobility variables. However, the acute effects of this training are still unknown. The acute effects of WBVT on neuromuscular performance, mobility and rating of perceived exertion (RPE) were evaluated in 1...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionsFP clinically classified as peripheral may be caused by central lesions in the cortex or pons and not only by peripheral facial nerve damage. In MS patients, FP may appear at the onset of the disease and be misdiagnosed as Bell ’s palsy. Clinicians should carefully approach FP diagnosis and perform a brain as well as temporal bone MRI before pursuing pharmacological treatment.Graphical Abstract
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Lisbet Marstrand, Ole Østerberg, Trine Walsted, Amalie C. Skov, Karen I. Schreiber, Finn SellebjergAbstractBackgroundCognitive impairment is highly prevalent in multiple sclerosis (MS). Due to the lack of specialized neuropsychological resources in many MS clinics, a brief cognitive monitoring tool that can be administered by other MS clinic staff is needed. BICAMS (Brief International Cognitive As-sessment for Multiple Sclerosis) has been developed and recommended by MS experts to monitor MS-related cognitiv...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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