ERp29 inhibition attenuates TCA toxicity via affecting p38/p53- dependent pathway in human trophoblast HTR-8/SVeno cells.

In this study, the function of ERp29 was further explored using in vitro model of ICP. The results showed that up-regulation of ERp29 occurred in TCA (taurocholic acid)-treated human trophoblast HTR-8/SVeno cells, and ERp29 inhibition reversed TCA toxicity via attenuating G2/M arrest and cell apoptosis. Mechanical study revealed ERp29 inhibition suppressed phosphorylation and kinase activity of p38, thus subsequently affecting expression and phosphorylation of p53 (ser18) as well as the transcriptional activity of p53. The conduction of this study might confirm the important role of ERp29 in ICP and which would be helpful for the development of target therapeutic method for ICP.
PMID: 31586554 [PubMed - as supplied by publisher]

Source: Archives of Biochemistry and Biophysics - October 2, 2019 Category: Biochemistry Authors: Zou S, Zou P, Wang Y, Dong R, Wang J, Li N, Wang T, Zhou T, Chen Z, Zhang Y, Chen M, Zhou C, Zhang T, Luo L Tags: Arch Biochem Biophys Source Type: research