Silver-Promoted Versatile Cross-Dehydrogenative Coupling of Quinaldine with Usual Ethers

Synlett DOI: 10.1055/s-0039-1690697 The application of small molecules as synthetic blocks is a field of great meaning and full of challenges, especially the use of inert ether molecules, such as THF as starting materials. A versatile and easily handled cross-dehydrogenative coupling between ethers and quinaldine is reported here. Compared to the developed reaction, Selectfluor is used as a mild oxidant, and a variety of functional groups are tolerated. Nitrogen protection, anhydrous systems, and external base are not needed, making this method a convenient route to functional heterocycles. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - October 6, 2019 Category: Chemistry Authors: Wang, Shoufeng Fan, Yafei Zhao, Huaiqing Wang, Jianfeng Zhang, Shuxiang Wang, Wengui Tags: letter Source Type: research