Hydrogen-Bond-Promoted Metal-Free Hydroamination of Alkynes

Synlett DOI: 10.1055/s-0039-1690988 An original metal-free regio- and stereoselective intermolecular hydroamination of alkynes is described. Various (E)-enamines were obtained from arylacetylenes and aliphatic secondary amines in the presence of ethylene glycol as a solvent. The latter is assumed to play a major role in the mechanism through hydrogen bonding and proton exchange. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - October 6, 2019 Category: Chemistry Authors: Bahri, Janet Tanbouza, Nour Ollevier, Thierry Taillefer, Marc Monnier, Florian Tags: letter Source Type: research