Impact of CYP3A4/5 and ABCB1 polymorphisms on tacrolimus exposure and response in pediatric primary nephrotic syndrome

Pharmacogenomics,Volume 20, Issue 15, Page 1071-1083, October 2019.
Source: Future Medicine: Pharmacogenomics - Category: Genetics & Stem Cells Authors: Source Type: research

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Publication date: Available online 29 March 2020Source: Journal of EthnopharmacologyAuthor(s): Xiao-wan Wang, Rui-min Tian, Yi-qi Yang, Kai Wang, En-nian Li, Xiao-dong Han, Kun Bao, Wei Mao, Hong-tao Xu, Bo Liu, Peng Xu
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractIdiopathic nephrotic syndrome is the most common glomerulopathy in childhood characterised by heavy proteinuria, hypoalbuminemia and edema. Most of the patients have mild and transient edema but those with difficult to treat nephrotic syndrome can develop severe edema which may have serious consequences such as immobility, cellulitis and peritonitis. Understanding of the pathophysiology of edema is still evolving with recent research elucidating newer mechanism of sodium retention through plasmin mediated epithelial sodium channel activation in collecting duct. Patients with mild edema do not require specific diure...
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
Condition:   Thyroid Dysfunction Intervention:   Diagnostic Test: Nephrotic patients Sponsors:   Merna Makram;   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Nephrotic syndrome and Giant cell arthritis concurrently occurring after percutaneous transluminal angioplasty for renal artery stenosis
. Clin Nephrol. 2020 Mar 26;: Authors: Ishizaki Y, Nishizono R, Sato Y, Ishikawa T, Kitamura K, Fujimoto S Abstract An elderly Japanese woman with bilateral renal artery occlusion who developed massive proteinuria after unilateral percutaneous transluminal renal angioplasty (PTRA) is reported. She had a history of percutaneous coronary intervention and subsequently developed refractory hypertension. She was diagnosed with renovascular hypertension caused by bilater...
Source: Clinical Nephrology - Category: Urology & Nephrology Authors: Tags: Clin Nephrol Source Type: research
AbstractBackgroundArterial stiffness is associated with an increased risk of cardiovascular diseases. Augmentation index (AIx@75), a measure of arterial stiffness and wave reflection, has not been evaluated in patients with primary nephrotic syndrome (PNS). We investigated whether central and peripheral vascular profiles, hemodynamic parameters, and biochemical tests are associated with AIx@75 in PNS patients.MethodsThis observational study involved 38 children and adolescents with PNS (12.14  ± 3.65 years) and 37 healthy controls (13.28 ± 2.80 years). Arterial stiffness ...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
A 12 ‐year‐old boy received steroid for his minimal change nephrotic syndrome for 10 years, and bilateral renal and ureteral stones and hydronephrosis were observed. Single‐use flexible ureteroscopy is usable for pediatric lithotripsy with Ho: YAG laser. AbstractA 12 ‐year‐old boy received steroid for his minimal change nephrotic syndrome for 10 years, and bilateral renal and ureteral stones and hydronephrosis were observed. Single‐use flexible ureteroscopy is usable for pediatric lithotripsy with Ho: YAG laser.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
ConclusionsIn treating children with uncomplicated NS, both BSA and BW regimens were equally effective in achieving initial remission and maintaining disease remission. Due to fewer adverse events and lesser cumulative steroid exposure with BW based regimen, it may be considered as better option over BSA regimen.Clinical trial registry nameClinical Trial Registry of India (CTRI/2015/03/005655)
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
The objectives of this study were to analyze in-hospital adverse drug events (ADEs) in Portuguese public hospitals, and their association with mortality and the duration of hospitalization. We analyzed an administrative database containing the registration of all hospitalizations occurring in Portuguese public hospitals in 2013-2015. ADEs were identified using the codes E850-858.9 and E930-949.9 from ICD-9-CM. We identified all episodes with registration of in-hospital ADE and we compared them with a random sample of an equal number of episodes with no events recorded. A total of 3,041,443 cases were analyzed, 60,521 prese...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
Authors: Han S, Yao T, Lu Y, Lu Y, Xu Y, Wang Y Abstract Primary nephrotic syndrome (PNS) is a common renal disease that presents with heavy proteinuria and hypoalbuminemia. Despite notable advances in its treatment, some patients show poor responses and clinical outcomes when treated with conventional Western medicine (WM). Chinese herbal injections (CHIs) have been reported to have beneficial effects for PNS. The aim of the present study was to comprehensively determine the efficacy and safety of CHIs for PNS in adults using a network meta-analysis approach. PubMed, Embase, the Cochrane library, and four Chinese ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
AbstractBackgroundHematuria is a common problem in pediatric practice and necessitates exhausting studies to detect etiology and establish proper management and counselling.Subjects and methodsWe reviewed the clinical and pathological findings in 95 children presented between 2013 and 2019 with gross or microscopic hematuria with or without proteinuria in whom non-glomerular causes were excluded. In addition, a reference range for normal glomerular basement membrane thickness (GBMT) is introduced based on the assessment of biopsies of 20 steroid-resistant nephrotic syndrome cases aged 3 –15 years, and with minim...
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
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