Voltage-gated sodium channel inhibitor reduces atherosclerosis by modulating monocyte/macrophage subsets and suppressing macrophage proliferation.

In conclusion, blockade of VGSCs in the mononuclear phagocyte system reduced atherosclerotic lesions, which may occur through altering monocyte/macrophage subsets and suppressing macrophage proliferation in atherosclerotic plaques. Blockage of VGSCs may play an important role in cardiovascular protection.
PMID: 31586905 [PubMed - as supplied by publisher]

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 2, 2019 Category: Drugs & Pharmacology Authors: Sun H, Jiang J, Gong L, Li X, Yang Y, Luo Y, Guo Z, Lu R, Li H, Li J, Zhao J, Yang N, Li Y Tags: Biomed Pharmacother Source Type: research